Title:
PURINE AND PYRIMIDINE CDK INHIBITORS AND THEIR USE FOR THE TREATMENT OF AUTOIMMUNE DISEASES
Document Type and Number:
WIPO Patent Application WO2006021803
Kind Code:
A3
Abstract:
The present invention relates to the use of an inhibitor of CDK2 and/or CDK7 and/or CDK9, or a pharmaceutically acceptable salt thereof, in the preparation of a medicament for treating a disease associated with antinuclear antibodies, wherein the inhibitor of CDK2 and/or CDK7 and/or CDK9 or pharmaceutically acceptable salt thereof is administered in an amount sufficient to down-regulate the levels of antinuclear antibodies. A further aspect of the invention relates to a combination comprising an inhibitor of CDK2 and/or CDK7 and/or CDK9, or a pharmaceutically acceptable salt thereof, and methylprednisolone, and its use in the treatment of diseases associated with antinuclear antibodies, such as SLE.
Inventors:
BENIGNI ARIELA (IT)
ZOJA CARLA (IT)
REMUZZI GIUSEPPE (IT)
GIANNELLA-BORRADORI ATHOS
ZOJA CARLA (IT)
REMUZZI GIUSEPPE (IT)
GIANNELLA-BORRADORI ATHOS
Application Number:
PCT/GB2005/003350
Publication Date:
April 20, 2006
Filing Date:
August 25, 2005
Export Citation:
Assignee:
CYCLACEL LTD (GB)
BENIGNI ARIELA (IT)
ZOJA CARLA (IT)
REMUZZI GIUSEPPE (IT)
GIANNELLA-BORRADORI ATHOS
BENIGNI ARIELA (IT)
ZOJA CARLA (IT)
REMUZZI GIUSEPPE (IT)
GIANNELLA-BORRADORI ATHOS
International Classes:
A61K31/52; A61K31/505; A61P19/02; A61P37/06; A61P43/00
Domestic Patent References:
| WO2005047526A2 | 2005-05-26 | |||
| WO1998005335A1 | 1998-02-12 | |||
| WO2003029248A1 | 2003-04-10 | |||
| WO2001072745A1 | 2001-10-04 | |||
| WO2004043953A1 | 2004-05-27 | |||
| WO2004056368A1 | 2004-07-08 | |||
| WO2004043467A1 | 2004-05-27 |
Foreign References:
| US20030229105A1 | 2003-12-11 | |||
| DE10127581A1 | 2003-01-02 |
Other References:
GRAY N ET AL: "ATP-SITE DIRECTED INHIBITORS OF CYCLIN-DEPENDENT KINASES", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 6, no. 9, September 1999 (1999-09-01), pages 859 - 875, XP000856195, ISSN: 0929-8673
GUZI T: "CYC-202", CURRENT OPINION IN INVESTIGATIONAL DRUGS, PHARMAPRESS, US, vol. 5, no. 12, December 2004 (2004-12-01), pages 1311 - 1318, XP008042931, ISSN: 1472-4472
GUZI T: "CYC-202", CURRENT OPINION IN INVESTIGATIONAL DRUGS, PHARMAPRESS, US, vol. 5, no. 12, December 2004 (2004-12-01), pages 1311 - 1318, XP008042931, ISSN: 1472-4472
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