Title:
PURINE SKELETON-BASED NO-WASH AGGREGATION-INDUCED PLASMA MEMBRANE TARGETED STAINING REAGENT, PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/155743
Kind Code:
A1
Abstract:
Disclosed in the present invention is a purine skeleton-based no-wash, aggregation-induced plasma membrane targeted staining reagent, and a preparation method and an application thereof, the present invention using a purine skeleton as a base for a plasma membrane stain, obtaining, by means of reasonable design regulating a fat-soluble end and a hydrophilic end, a purine skeleton-based plasma membrane targeted staining reagent, the reagent being capable of both rapid targeted staining and remaining on a plasma membrane for a relatively long time, benefiting long-term detection. In addition, given that the staining reagent has characteristics of an aggregation-induced compound, emitting light weakly or not emitting light in solution, and exhibiting strong fluorescence when not in solution, causing the stain to further have specific no-wash performance. The preparation method of the present invention has high yield and mild reaction conditions, and the prepared staining reagent has a large Stokes shift and high targeting.
Inventors:
LI KUN (CN)
SHI LEI (CN)
YU XIAOQI (CN)
LIU YANHONG (CN)
YU KANGKANG (CN)
SHI LEI (CN)
YU XIAOQI (CN)
LIU YANHONG (CN)
YU KANGKANG (CN)
Application Number:
PCT/CN2019/117083
Publication Date:
August 06, 2020
Filing Date:
November 11, 2019
Export Citation:
Assignee:
UNIV SICHUAN (CN)
International Classes:
C07D473/34; C07D473/00; C09B23/14; C09K11/06; G01N1/30; G01N21/64
Foreign References:
| CN105367566A | 2016-03-02 |
Attorney, Agent or Firm:
RUNPING & PARTNERS (CN)
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