Title:
PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES
Document Type and Number:
WIPO Patent Application WO2002024681
Kind Code:
A3
Abstract:
The present invention provides pyrazine derivatives that inhibit tyrosine kinase activity. Certain pyrazine derivatives are selective inhibitors of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. The present invention also provides pharmaceutical formulations containing the pyrazine derivatives and methods of use of these formulations as anti-tumor agents and to treat solid-tumor cancers, angiogenesis, diabetic retinopathy, rheumatoid arthritis, endometriosis and psoriasis.
Inventors:
KUO GEE HONG
CONNOLLY PETER
PROUTY CATHERINE
DEANGELIS ALAN
WANG AIHUA
JOLLIFFE LINDA
MIDDLETON STEVE
EMANUEL STUART
CONNOLLY PETER
PROUTY CATHERINE
DEANGELIS ALAN
WANG AIHUA
JOLLIFFE LINDA
MIDDLETON STEVE
EMANUEL STUART
Application Number:
PCT/US2001/029175
Publication Date:
June 20, 2002
Filing Date:
September 19, 2001
Export Citation:
Assignee:
ORTHO MCNEIL PHARM INC (US)
International Classes:
C07D241/20; A61K31/4965; A61K31/497; A61K31/5377; A61P9/00; A61P15/00; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07D401/04; C07D401/14; C07D405/12; C07D405/14; C07D417/04; (IPC1-7): C07D401/04; C07D401/14; C07D405/14; A61K31/495; A61P35/00
Domestic Patent References:
| WO2001060806A2 | 2001-08-23 |
Foreign References:
| US4514400A | 1985-04-30 |
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