Title:
PYRAZOLE COMPOUND AND MEDICINAL COMPOSITION CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2003/101968
Kind Code:
A1
Abstract:
A novel compound having excellent JNK inhibitory activity. It is a compound represented by the following general formula or a salt thereof. (I) In the formula, R1 represents -(CO)h-(NRa)j-(CRb=CRc)k-Ar (wherein Ra, Rb, and Rc each independently represents hydrogen, halogeno, hydroxy, optionally substituted C1-6 alkyl, etc.); Cy means a 5- or 6-membered aromatic heterocycle; and V's each independently means -L-X-Y [wherein L means a single bond, optionally substituted C1-6 alkylene, etc.; X means a single bond, -A- (wherein A represents NR2, O, CO, S, SO, or SO2), etc.; and Y means hydrogen, halogeno, nitro, etc.].
Inventors:
OHI NORIHITO (JP)
SATO NOBUAKI (JP)
SOEJIMA MOTOHIRO (JP)
DOKO TAKASHI (JP)
TERAUCHI TARO (JP)
NAOE YOSHIMITSU (JP)
MOTOKI TAKAFUMI (JP)
SATO NOBUAKI (JP)
SOEJIMA MOTOHIRO (JP)
DOKO TAKASHI (JP)
TERAUCHI TARO (JP)
NAOE YOSHIMITSU (JP)
MOTOKI TAKAFUMI (JP)
Application Number:
PCT/JP2003/006777
Publication Date:
December 11, 2003
Filing Date:
May 29, 2003
Export Citation:
Assignee:
EISAI CO LTD (JP)
OHI NORIHITO (JP)
SATO NOBUAKI (JP)
SOEJIMA MOTOHIRO (JP)
DOKO TAKASHI (JP)
TERAUCHI TARO (JP)
NAOE YOSHIMITSU (JP)
MOTOKI TAKAFUMI (JP)
OHI NORIHITO (JP)
SATO NOBUAKI (JP)
SOEJIMA MOTOHIRO (JP)
DOKO TAKASHI (JP)
TERAUCHI TARO (JP)
NAOE YOSHIMITSU (JP)
MOTOKI TAKAFUMI (JP)
International Classes:
A61K31/407; A61K31/416; A61K31/4162; A61K31/4178; A61K31/4184; A61K31/4196; A61K31/42; A61K31/422; A61K31/4245; A61K31/427; A61K31/43; A61K31/437; A61K31/4439; A61K31/444; A61K31/454; A61K31/496; A61K31/497; A61K31/4985; A61K31/506; A61K31/5377; A61K31/55; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P37/06; A61P43/00; C07D231/56; C07D401/06; C07D403/04; C07D403/06; C07D405/06; C07D409/04; C07D409/06; C07D413/04; C07D413/14; C07D471/04; C07D487/04; C07D495/04; (IPC1-7): C07D231/56; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D471/04; C07D495/04; C07D519/00; C07D471/08; C07D487/04; C07D401/06; C07D405/14; C07D409/06; C07D403/04; C07D401/14; C07D413/14; C07D417/12; C07D413/12; C07D405/06; C07D403/06; C07D417/14; C07D413/04; A61K31/416; A61K31/4162; A61K31/437; A61K31/43; A61K31/444; A61K31/422; A61K31/4196; A61K31/454; A61K31/496; A61K31/5377; A61K31/506; A61K31/497; A61K31/42; A61K31/4985; A61K31/4439; A61K31/4178; A61K31/4184; A61K31/427; A61K31/55; A61K31/4245; A61K31/407; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P37/06; A61P43/00
Domestic Patent References:
| WO2002083648A1 | 2002-10-24 | |||
| WO2000056710A1 | 2000-09-28 | |||
| WO1999020624A1 | 1999-04-29 | |||
| WO1999007705A1 | 1999-02-18 | |||
| WO1998052948A1 | 1998-11-26 |
Foreign References:
| EP0594001A1 | 1994-04-27 | |||
| EP0239191A2 | 1987-09-30 | |||
| JPH01190681A | 1989-07-31 | |||
| SU1147712A1 | 1985-03-30 |
Other References:
DATABASE ACS [online] ABDEL-AZIZ EL-TAWEEL ET AL.: "Heterocyclic amidines: synthesis of new azaindene derivatives", XP002971383, accession no. STN Database accession no. 129:81707
DATABASE ACS [online] GHOZLAN S.A.S. ET AL.: "Nitriles in organic synthesis: synthesis of some new polyfunctionally substituted pyrazines and fused pyrazines", XP002971384, accession no. STN Database accession no. 121:35536
DATABASE ACS [online] MAREI MOHAMED GABER: "Preparation and reactions of 6-aryl-1, 5-dihydro-3-phenyl-4H-pyrazolo(4,3-c)pyridin-4-ones", XP002971385, accession no. STN Database accession no. 119:139165
DATABASE ACS [online] RUSINOV V.L. ET AL.: "Nitro azines. 20. Simple syntheses of pyrazolo-condensed nitropyridines from aliphatic nitro synthons and ainopyrazoles", XP002971386, accession no. STN Database accession no. 119:49293
DATABASE ACS [online] MAREI MOHAMED GABER: "Preparation and reactions of pyrazolo (4,3-c)pyridin-4(5H)-ones", XP002971387, accession no. STN Database accession no. 119:28050
DATABASE ACS [online] RADINOV R.: "3-Phenylpyrazolo(4,3-c)pyridine and derivatives: structure determination", XP002971388, accession no. STN Database accession no. 108:111448
DATABASE ACS [online] CECCHI L. ET AL.: "Synthesis of 1-N-glycosides of 3-Phenylpyrazolo(4,5-b)pyrazine", XP002971389, accession no. STN Database accession no. 98:143780
DATABASE ACS [online] CECCHI L. ET AL.: "Reaction of 3-phenyl-4,5-diamonopyrazole with 1,2-dioxo compounds 3-phenylpyrazolo(4,5-b)pyrazines", XP002971390, accession no. STN Database accession no. 96:142805
DATABASE ACS [online] JOSHI A.: "Synthesis of some new fluorine-containing 5-amino-1,3-disubstituted pyrazoles and 1H-pyrazolo(3,4-b)pyridines", XP002971391, accession no. STN Database accession no. 92:146665
DATABASE ACS [online] KOCEVAR M. ET AL.: "3-Diazopyrazolo(3,4-b)pyridine, a versatile synthon for new heterocyclic systems", XP002971392, accession no. STN Database accession no. 90:22859
See also references of EP 1510516A4
DATABASE ACS [online] GHOZLAN S.A.S. ET AL.: "Nitriles in organic synthesis: synthesis of some new polyfunctionally substituted pyrazines and fused pyrazines", XP002971384, accession no. STN Database accession no. 121:35536
DATABASE ACS [online] MAREI MOHAMED GABER: "Preparation and reactions of 6-aryl-1, 5-dihydro-3-phenyl-4H-pyrazolo(4,3-c)pyridin-4-ones", XP002971385, accession no. STN Database accession no. 119:139165
DATABASE ACS [online] RUSINOV V.L. ET AL.: "Nitro azines. 20. Simple syntheses of pyrazolo-condensed nitropyridines from aliphatic nitro synthons and ainopyrazoles", XP002971386, accession no. STN Database accession no. 119:49293
DATABASE ACS [online] MAREI MOHAMED GABER: "Preparation and reactions of pyrazolo (4,3-c)pyridin-4(5H)-ones", XP002971387, accession no. STN Database accession no. 119:28050
DATABASE ACS [online] RADINOV R.: "3-Phenylpyrazolo(4,3-c)pyridine and derivatives: structure determination", XP002971388, accession no. STN Database accession no. 108:111448
DATABASE ACS [online] CECCHI L. ET AL.: "Synthesis of 1-N-glycosides of 3-Phenylpyrazolo(4,5-b)pyrazine", XP002971389, accession no. STN Database accession no. 98:143780
DATABASE ACS [online] CECCHI L. ET AL.: "Reaction of 3-phenyl-4,5-diamonopyrazole with 1,2-dioxo compounds 3-phenylpyrazolo(4,5-b)pyrazines", XP002971390, accession no. STN Database accession no. 96:142805
DATABASE ACS [online] JOSHI A.: "Synthesis of some new fluorine-containing 5-amino-1,3-disubstituted pyrazoles and 1H-pyrazolo(3,4-b)pyridines", XP002971391, accession no. STN Database accession no. 92:146665
DATABASE ACS [online] KOCEVAR M. ET AL.: "3-Diazopyrazolo(3,4-b)pyridine, a versatile synthon for new heterocyclic systems", XP002971392, accession no. STN Database accession no. 90:22859
See also references of EP 1510516A4
Attorney, Agent or Firm:
Furuya, Satoshi (2-17-8 Nihonbashi-Hamach, Chuo-ku Tokyo, JP)
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