PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME

Title:

PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME

Document Type and Number:

WIPO Patent Application WO/2006/126695

Kind Code:

A1

Abstract:

A pyrazole compound represented by the general formula (I) or a salt thereof which has a hepatic glycogen phosphorylase inhibitory activity and therefore is useful as a therapeutic or prophylactic agent for diabetes or a pharmacologically salt thereof : wherein the ring Q represents an aryl group or an aromatic heterocyclic group; R¹ represents a hydrogen atom, a halogen atom, a C_1-6 alkyl group or a C_1-6 alkoxy group; R² represents a halogen atom, a C_1-6 alkyl group, a C_1-6 alkoxy group or an azide group; R³ represents a halogen atom, a hydroxyl group, a C_1-6 alkyl group, a halo-C_1-6 alkyl group, a C_1-6 alkoxy group, an azide group, an amino group, an acylamino group or a C_1-6 alkylsulfonylamino group; R⁴ and R⁵ independently represent a hydrogen atom, a C_1-6 alkyl group which may be substituted, a a C_3-8 cycloalkyl group, a saturated heterocyclic group which may be substituted, an aryl group which may be substituted, a C_7-14 aralkyl group, an aromatic heterocyclic group or the like.

Inventors:

TAKAGI MASAKI (JP)
NAKAMURA TAKESHI (JP)
MATSUDA ISAMU (JP)
FUKUDA KENJI (JP)
OZAWA KOICHI (JP)
UEDA NOBUHISA (JP)
SAKATA KAORU (JP)
NOMURA YUKIHIRO (JP)

Application Number:

PCT/JP2006/310603

Publication Date:

November 30, 2006

Filing Date:

May 22, 2006

Export Citation:

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Assignee:

JAPAN TOBACCO INC (JP)
TAKAGI MASAKI (JP)
NAKAMURA TAKESHI (JP)
MATSUDA ISAMU (JP)
FUKUDA KENJI (JP)
OZAWA KOICHI (JP)
UEDA NOBUHISA (JP)
SAKATA KAORU (JP)
NOMURA YUKIHIRO (JP)

International Classes:

A61K31/41; C07D231/40; A61K31/415; A61K31/4155; A61K31/4184; A61K31/4192; A61K31/4196; A61K31/422; A61K31/4245; A61K31/427; A61K31/428; A61K31/433; A61K31/4439; A61K31/444; A61K31/4453; A61K31/454; A61K31/455; A61K31/47; A61K31/4709; A61K31/4725; A61K31/4965; A61K31/517; A61K31/5377; A61K31/541; A61K31/64; A61P3/04; A61P3/06; A61P3/10; A61P43/00; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D417/14

Domestic Patent References:

WO2004098589A1	2004-11-18
WO2004098590A1	2004-11-18
WO2003015774A1	2003-02-27

Other References: