Title:
4−&lpar 4−PYRIDAZINYL&rpar PYRAZOLE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2002/092593
Kind Code:
A1
Abstract:
4−(4−Pyridazinyl)pyrazole derivatives represented by the following general formula or salts thereof have an excellent p38MAP kinase inhibitory activity, which makes them useful in preventing or treating tumor necrosis factor−&agr −associated diseases, interleukin−1−associated diseases, interleukin−6−associated diseases or cyclooxygenase II−associated diseases: (I) wherein Q represented optionally substituted aryl, etc.&semi R1 represents hydrogen, halogeno, etc.&semi R2 represents hydrogen, lower alkyl, etc.&semi and R3 represents hydrogen, −CH2−CH(R4)−(A)n−Y (wherein A represents lower alkylene&semi Y represents optionally substituted aryl&semi R4 represents hydrogen or lower alkyl&semi and n is 0 or 1), etc.
Inventors:
MINAMI NOBUYOSHI (JP)
HASUMI KOICHI (JP)
OHTA SHUJI (JP)
SATO SHUICHIRO (JP)
SAITO TAKAHISA (JP)
DOI SATOSHI (JP)
KOBAYASHI MOTOHIRO (JP)
SATO JUN (JP)
ASANO HAJIME (JP)
MATSUMOTO YASUHIRO (JP)
HASUMI KOICHI (JP)
OHTA SHUJI (JP)
SATO SHUICHIRO (JP)
SAITO TAKAHISA (JP)
DOI SATOSHI (JP)
KOBAYASHI MOTOHIRO (JP)
SATO JUN (JP)
ASANO HAJIME (JP)
MATSUMOTO YASUHIRO (JP)
Application Number:
PCT/JP2002/004636
Publication Date:
November 21, 2002
Filing Date:
May 14, 2002
Export Citation:
Assignee:
TEIKOKU HORMONE MFG CO LTD (JP)
MINAMI NOBUYOSHI (JP)
HASUMI KOICHI (JP)
OHTA SHUJI (JP)
SATO SHUICHIRO (JP)
SAITO TAKAHISA (JP)
DOI SATOSHI (JP)
KOBAYASHI MOTOHIRO (JP)
SATO JUN (JP)
ASANO HAJIME (JP)
MATSUMOTO YASUHIRO (JP)
MINAMI NOBUYOSHI (JP)
HASUMI KOICHI (JP)
OHTA SHUJI (JP)
SATO SHUICHIRO (JP)
SAITO TAKAHISA (JP)
DOI SATOSHI (JP)
KOBAYASHI MOTOHIRO (JP)
SATO JUN (JP)
ASANO HAJIME (JP)
MATSUMOTO YASUHIRO (JP)
International Classes:
C07D401/14; A61K31/501; A61P1/00; A61P1/04; A61P1/18; A61P3/10; A61P7/00; A61P7/02; A61P9/04; A61P9/08; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P15/06; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P19/06; A61P19/08; A61P19/10; A61P25/00; A61P25/28; A61P29/00; A61P29/02; A61P31/18; A61P33/06; A61P35/00; A61P37/02; A61P43/00; C07D403/04; C07D405/14; (IPC1-7): C07D401/14; A61K31/501; A61P1/00; A61P1/04; A61P1/18; A61P3/10; A61P7/00; A61P7/02; A61P9/04; A61P9/08; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P15/06; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P19/06; A61P19/08; A61P19/10; A61P25/00; A61P25/28; A61P29/00; A61P29/02; A61P31/18; A61P33/06; A61P35/00; A61P37/02; A61P43/00; C07D403/04; C07D405/14
Domestic Patent References:
| WO2000075131A1 | 2000-12-14 | |||
| WO2000039116A1 | 2000-07-06 | |||
| WO1998056377A1 | 1998-12-17 |
Attorney, Agent or Firm:
Odajima, Heikichi (Nippon Jitensha Bldg. 9-15, Akasaka 1-chom, Minato-ku Tokyo, JP)
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