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Title:
PYRAZOLE-TRIAZINE DERIVATIVES, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND USE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2017/190708
Kind Code:
A1
Abstract:
Provided in the present invention are a compound as represented by formula (I), a cis-trans isomer, an enantiomer, a diastereoisomer, a racemate, a solvate, and a hydrate thereof or a pharmaceutically acceptable salt and ester thereof, a preparation method therefor, a pharmaceutical composition containing said compound, and a use for said compound as a α5-GABAA receptor modulator, Z, A, and Y of said formula being defined in the description.

Inventors:
LI, Shuai (407 Zhaojiabang Road, Xuhui District, Shanghai 2, 200032, CN)
SUN, Yong (Room 601, Building 4 Lane 580, Kanghong Road, Kangqiao Town, Pudong District, Shanghai 5, 201315, CN)
Application Number:
CN2017/083407
Publication Date:
November 09, 2017
Filing Date:
May 08, 2017
Export Citation:
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Assignee:
RUDONG SIMR BIOTECH CO., LTD (#888 Street Zhujiang, Juegang Town Rudon, Nantong Jiangsu 0, 226400, CN)
International Classes:
C07D487/04; A61K31/53; A61K31/5377; A61K31/541; A61P9/10; A61P21/00; A61P25/02; A61P25/04; A61P25/28; A61P25/30; A61P29/00
Domestic Patent References:
WO2001077111A12001-10-18
Foreign References:
CN103239720A2013-08-14
CN1391574A2003-01-15
Other References:
JONES, PHILIP. ET AL.: "Pharmacokinetics and metabolism studies on (3- tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1, 2, 4-tria- zol-5-ylmethoxy)pyrazolo[1, 5-d][1, 2, 4]triazine), a functionally sele- ctive GABAA a 5 inverse agonist for cognitive dysfunction", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 4, 15 February 2006 (2006-02-15), pages 872 - 875, XP027965770, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2005.11.012
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (435 Guiping Road, Shanghai 3, 200233, CN)
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