Title:
PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2018/000550
Kind Code:
A1
Abstract:
Disclosed is a pyrazolo [3,4-d] pyrimidine derivative represented by the formula (I), having a significant inhibitory effect on tumour cells, and being used for the prevention or treatment of tumour-related diseases, particularly lung cancer, having prospects for wide application.
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Inventors:
HE YANG (CN)
LI WEIMIN (CN)
ZHANG LI (CN)
CHEN BOJIANG (CN)
QIU ZHIXIN (CN)
LI WEIMIN (CN)
ZHANG LI (CN)
CHEN BOJIANG (CN)
QIU ZHIXIN (CN)
Application Number:
PCT/CN2016/095504
Publication Date:
January 04, 2018
Filing Date:
August 16, 2016
Export Citation:
Assignee:
WEST CHINA HOSPITAL SICHUAN UNIV (CN)
International Classes:
C07D487/04; A61K31/4985; A61K31/519; A61P35/00; C07D471/04
Domestic Patent References:
| WO2013102059A1 | 2013-07-04 |
Foreign References:
| CN102596963A | 2012-07-18 |
Other References:
APSEL, B. ET AL.: "Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases", NATURE CHEMICAL BIOLOGY, vol. 4, no. 11, 12 October 2008 (2008-10-12), pages 691 - 699, XP007909493, ISSN: 1552-4450, DOI: 10.1038/nchembio.117
T ANAKA, M. ET AL.: "An Unbiased Cell Morphology-Based Screen for New, Biologically Active Small Molecules", PLOS BIOLOGY, vol. 3, no. 5, 5 April 2005 (2005-04-05), pages 764 (e128) - 776, XP002473053, ISSN: 1544-9173, DOI: 10.1371/journal.pbio.0030128
SCHENONE, S. ET AL.: "Biologically Driven Synthesis of Pyrazolo[3, 4- d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies", CHEMICAL REVIEWS, vol. 114, 29 May 2014 (2014-05-29), pages 7189 - 7238, XP055124838, ISSN: 0009-2665, DOI: 10.1021/cr400270z
T ANAKA, M. ET AL.: "An Unbiased Cell Morphology-Based Screen for New, Biologically Active Small Molecules", PLOS BIOLOGY, vol. 3, no. 5, 5 April 2005 (2005-04-05), pages 764 (e128) - 776, XP002473053, ISSN: 1544-9173, DOI: 10.1371/journal.pbio.0030128
SCHENONE, S. ET AL.: "Biologically Driven Synthesis of Pyrazolo[3, 4- d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies", CHEMICAL REVIEWS, vol. 114, 29 May 2014 (2014-05-29), pages 7189 - 7238, XP055124838, ISSN: 0009-2665, DOI: 10.1021/cr400270z
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY(GENERAL PARTNERSHIP) (CN)
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