Title:
PYRAZOLOPYRIDINONE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2023/011456
Kind Code:
A1
Abstract:
Disclosed herein is a compound of Formula (I) for activating T cells, promoting T cell proliferation, and/or exhibiting antitumor activity, a method of using the compounds disclosed herein for treating cancer, and a pharmaceutical composition comprising the same.
Inventors:
ZHANG GUOLIANG (CN)
NI ZHIKUN (CN)
MIAO JIANZHUANG (CN)
WANG CE (CN)
NI ZHIKUN (CN)
MIAO JIANZHUANG (CN)
WANG CE (CN)
Application Number:
PCT/CN2022/109663
Publication Date:
February 09, 2023
Filing Date:
August 02, 2022
Export Citation:
Assignee:
BEIGENE LTD (GB)
ZHANG GUOLIANG (CN)
ZHANG GUOLIANG (CN)
International Classes:
C07D471/04; A61K31/437; A61K31/444; A61K31/5517; A61P35/00; C07D247/00; C07D401/02; C07D403/02
Domestic Patent References:
| WO2021001453A1 | 2021-01-07 | |||
| WO2005000304A1 | 2005-01-06 | |||
| WO2021074365A1 | 2021-04-22 | |||
| WO2005000303A1 | 2005-01-06 |
Other References:
ZHOU， SHU ET AL.: "Structure-based discovery of new maternal embryonic leucine zipper kinase inhibitors.", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 16, no. 9, 23 January 2018 (2018-01-23), pages 1489 - 1495, XP055749148, DOI: 10.1039/C7OB02344H
YAO DAHONG, ZHANG JIN, WANG JINHUI, PAN DABO, HE ZHENDAN: "Discovery of novel ATAD2 bromodomain inhibitors that trigger apoptosis and autophagy in breast cells by structure-based virtual screening", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, INFORMA HEALTHCARE, GB, vol. 35, no. 1, 1 January 2020 (2020-01-01), GB , pages 713 - 725, XP093033237, ISSN: 1475-6366, DOI: 10.1080/14756366.2020.1740924
YAO DAHONG, ZHANG JIN, WANG JINHUI, PAN DABO, HE ZHENDAN: "Discovery of novel ATAD2 bromodomain inhibitors that trigger apoptosis and autophagy in breast cells by structure-based virtual screening", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, INFORMA HEALTHCARE, GB, vol. 35, no. 1, 1 January 2020 (2020-01-01), GB , pages 713 - 725, XP093033237, ISSN: 1475-6366, DOI: 10.1080/14756366.2020.1740924
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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