Title:
PYRAZOLOPYRIMIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/048519
Kind Code:
A1
Abstract:
Provided are: a pyrazolopyrimidine compound having an inhibitory activity on NLRP3 inflammasomes or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing the same; a pharmaceutical use thereof, etc. A compound of formula [IA] or a pharmaceutically acceptable salt thereof (in the formula, each symbol is as defined in the specification).
More Like This:
Inventors:
OHBA YUSUKE (JP)
ADACHI KAORU (JP)
SAKURAI KENTARO (JP)
SATO SHIMPEI (JP)
ITO SHUNYA (JP)
ADACHI KAORU (JP)
SAKURAI KENTARO (JP)
SATO SHIMPEI (JP)
ITO SHUNYA (JP)
Application Number:
PCT/JP2023/030980
Publication Date:
March 07, 2024
Filing Date:
August 28, 2023
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
International Classes:
C07D487/04; A61K31/519; A61P1/04; A61P1/16; A61P3/06; A61P9/10; A61P19/02; A61P19/06; A61P21/02; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P37/02; A61P43/00; C07D519/00
Domestic Patent References:
| WO2022063896A1 | 2022-03-31 | |||
| WO2021242505A1 | 2021-12-02 | |||
| WO2023032987A1 | 2023-03-09 |
Foreign References:
| CN113549080A | 2021-10-26 |
Other References:
ABDULLAHA MOHD, MOHAMMED SHABBER, ALI MEHBOOB, KUMAR AJAY, VISHWAKARMA RAM A., BHARATE SANDIP B.: "Discovery of Quinazolin-4(3 H )-ones as NLRP3 Inflammasome Inhibitors: Computational Design, Metal-Free Synthesis, and in Vitro Biological Evaluation", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 84, no. 9, 3 May 2019 (2019-05-03), pages 5129 - 5140, XP093143049, ISSN: 0022-3263, DOI: 10.1021/acs.joc.9b00138
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
Download PDF: