Title:
PYRAZOLOPYRIMIDINE DERIVATIVES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR USE IN PREVENTING OR TREATING CANCER, AUTOIMMUNE DISEASE AND BRAIN DISEASE CONTAINING THE SAME AS AN ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2018/208132
Kind Code:
A1
Abstract:
The present invention relates to a pyrazolopyrimidine derivative, a preparation method thereof and a pharmaceutical composition comprising the same as an active ingredient for the prevention or treatment of cancer, autoimmune disease and brain disease. The pyrazolopyrimidine derivative of the present invention exhibits excellent Bruton's tyrosine kinase inhibition activity, so that it can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer, autoimmune disease and Parkinson's disease.
Inventors:
KIM PILHO (KR)
CHO SUNG YUN (KR)
HA JAE DU (KR)
KIM HYOUNG RAE (KR)
HWANG JONG YEON (KR)
YUN CHANG SOO (KR)
JUNG HEE JUNG (KR)
PARK CHI HOON (KR)
LEE CHONG OCK (KR)
LEE CHANG HOON (KR)
AHN SUNJOO (KR)
CHO SUNG YUN (KR)
HA JAE DU (KR)
KIM HYOUNG RAE (KR)
HWANG JONG YEON (KR)
YUN CHANG SOO (KR)
JUNG HEE JUNG (KR)
PARK CHI HOON (KR)
LEE CHONG OCK (KR)
LEE CHANG HOON (KR)
AHN SUNJOO (KR)
Application Number:
PCT/KR2018/005478
Publication Date:
November 15, 2018
Filing Date:
May 14, 2018
Export Citation:
Assignee:
KOREA RES INST CHEMICAL TECH (KR)
International Classes:
C07D487/04; A23L33/10; A61K31/519
Domestic Patent References:
| WO2007024680A1 | 2007-03-01 | |||
| WO2008112695A2 | 2008-09-18 | |||
| WO2015048689A1 | 2015-04-02 |
Other References:
WU, S. ET AL.: "Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 112, no. 50, 2015, pages 15480 - 15485, XP055556362
LEUNG, C. S. ET AL.: "Methyl Effects on Protein-Ligand Binding", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 9, 2012, pages 4489 - 4500, XP055556365
LEUNG, C. S. ET AL.: "Methyl Effects on Protein-Ligand Binding", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 9, 2012, pages 4489 - 4500, XP055556365
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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