Title:
PYRAZOLOQUINAZOLINE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/143576
Kind Code:
A1
Abstract:
The present invention relates to a pyrazoloquinazoline compound, and a preparation method therefor and the use thereof. The present invention particularly relates to a pyrazoloquinazoline compound as shown in formula I, a pharmaceutically acceptable salt thereof, a solvate thereof, or a solvate of the pharmaceutically acceptable salt thereof. The compound has an obvious inhibitory effect on PLK1.
Inventors:
WEI ZHAO (CN)
WANG WENYI (CN)
CUI HONG (CN)
LI YUANNIAN (CN)
ZHOU HONG (CN)
SHI FENG (CN)
WANG WENYI (CN)
CUI HONG (CN)
LI YUANNIAN (CN)
ZHOU HONG (CN)
SHI FENG (CN)
Application Number:
PCT/CN2021/141831
Publication Date:
July 07, 2022
Filing Date:
December 28, 2021
Export Citation:
Assignee:
NEWSOARA BIOPHARMA CO LTD (CN)
International Classes:
C07D487/04; A61K31/519; A61P35/00
Foreign References:
| CN101563351A | 2009-10-21 | |||
| CN1826343A | 2006-08-30 | |||
| CN102076689A | 2011-05-25 |
Other References:
AKSHADA J. JOSHI ET AL.: "Strategies to select the best pharmacophore model: a case study in pyrazoloquinazoline class of PLK-1 inhibitors", 《MED CHEM RES》, vol. 27, 12 September 2017 (2017-09-12), XP036389720, DOI: 10.1007/s00044-017-2057-9
ITALO BERIA ET AL.: "4, 5-Dihydro-1H-pyrazolo[4, 3-h]quinazolines as potent and selective Polo-like kinase 1 (PLK1) inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, 17 September 2010 (2010-09-17), XP086653874, DOI: 10.1016/j.bmcl.2010.09.060
ITALO BERIA ET AL.: "NMS-P937, a 4, 5-dihydro-1H-pyrazolo[4, 3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, 21 March 2011 (2011-03-21), XP028208761, DOI: 10.1016/j.bmcl.2011.03.054
DATABASE REGISTRY 8 July 2021 (2021-07-08), ANONYMOUS : "5H-Pyrrolo[3,2-h]quinazoline-7-carboxamide, 6,9-dihydro-9-methyl-2-[[5-(1-methyl-4-piperidinyl)-2- (trifluoromethoxy)phenyl]amino]-(CA INDEX NAME) ", XP055947762, retrieved from STN Database accession no. 2650909-28-5
ITALO BERIA ET AL.: "4, 5-Dihydro-1H-pyrazolo[4, 3-h]quinazolines as potent and selective Polo-like kinase 1 (PLK1) inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, 17 September 2010 (2010-09-17), XP086653874, DOI: 10.1016/j.bmcl.2010.09.060
ITALO BERIA ET AL.: "NMS-P937, a 4, 5-dihydro-1H-pyrazolo[4, 3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, 21 March 2011 (2011-03-21), XP028208761, DOI: 10.1016/j.bmcl.2011.03.054
DATABASE REGISTRY 8 July 2021 (2021-07-08), ANONYMOUS : "5H-Pyrrolo[3,2-h]quinazoline-7-carboxamide, 6,9-dihydro-9-methyl-2-[[5-(1-methyl-4-piperidinyl)-2- (trifluoromethoxy)phenyl]amino]-(CA INDEX NAME) ", XP055947762, retrieved from STN Database accession no. 2650909-28-5
Attorney, Agent or Firm:
JUN HE LAW OFFICES (CN)
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