PYRAZOLOXAZOLE COMPOUND

WIPO Patent Application WO/2011/043387

A1

Disclosed is a compound represented by formula (I) or a salt thereof, which has an excellent CRF receptor antagonist effect. (In the formula, R1 and R2 may be the same or different and each represents a hydrogen atom, a C1-6 alkyl group, a cyclic group (selected from among a C3-6 cycloalkyl group, a tetrahydropyranyl group, a dihydropyranyl group, a tetrahydrofuryl group, a dioxanyl group, a tetrahydrothienyl group, a dithianyl group and a hexahydrothiepinyl group), a C1-6 alkyl group that is substituted with a cyclic group (selected from among a C3-6 cycloalkyl group, a tetrahydropyranyl group, a dihydropyranyl group, a tetrahydrofuryl group, a dioxanyl group, a tetrahydrothienyl group, a dithianyl group and a hexahydrothiepinyl group), or the like; R3, R4 and R5 may be the same or different and each represents a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a C1-6 alkoxy group, a C1-6 alkoxy C1-6 alkyl group, a C3-6 cycloalkoxy C1-6 alkyl group or a halogen atom; R6 represents a hydrogen atom or a C1-6 alkyl group; and R7 represents a C1-6 alkyl group, a C1-6 alkoxy group or a C1-6 alkylthio group.)

SHIN KOGYOKU (GB)
TERAUCHI TARO (JP)
TAKAHASHI YOSHINORI (JP)
HASHIZUME MINAKO (JP)
TAKEDA KUNITOSHI (JP)
SHIKATA KODO (GB)
INOMATA AKIRA (JP)

PCT/JP2010/067564

April 14, 2011

October 06, 2010

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EISAI R&D MAN CO LTD (JP)
SHIN KOGYOKU (GB)
TERAUCHI TARO (JP)
TAKAHASHI YOSHINORI (JP)
HASHIZUME MINAKO (JP)
TAKEDA KUNITOSHI (JP)
SHIKATA KODO (GB)
INOMATA AKIRA (JP)

C07D491/048; A61K31/4162; A61P1/04; A61P9/00; A61P9/12; A61P25/00; A61P25/14; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P43/00

WO2002088121A1	2002-11-07
WO2004037822A1	2004-05-06
WO2009128383A1	2009-10-22
WO2010015628A1	2010-02-11
WO2002066439A1	2002-08-29

JP2009510004A	2009-03-12
JP2008517067A	2008-05-22
JP2008503444A	2008-02-07
JP2007515474A	2007-06-14
JP2009234111A	2009-10-15
USPP24974109P	2009-10-08
US20040224974A1	2004-11-11
US5234818A	1993-08-10

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HASEGAWA Yoshiki et al. (JP)
Yoshiki Hasegawa (JP)

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