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Title:
PYRAZOLYL-CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/076336
Kind Code:
A1
Abstract:
The present invention relates to a pyrazolyl-containing tricyclic derivative, a preparation method therefor and the use thereof. In particular, the present invention relates to a compound as shown in the general formula (I), a preparation method therefor and a pharmaceutical composition containing the compound, and the use thereof as a protease such as ERK (MAPK) inhibitor in the treatment of cancers, bone diseases, inflammatory diseases, immune diseases, nervous system diseases, metabolic diseases, respiratory diseases and heart diseases, wherein the definition of each substituent in the general formula (I) is the same as defined in the description.

Inventors:
LIU SHIQIANG (CN)
ZHOU YUANFENG (CN)
LIU YANG (CN)
WU XUESONG (CN)
LIU LEI (CN)
BAO RUDI (CN)
Application Number:
PCT/CN2018/110795
Publication Date:
April 25, 2019
Filing Date:
October 18, 2018
Export Citation:
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Assignee:
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
International Classes:
A61K31/415; C07D471/04; A61K31/4162; A61P35/00; A61P35/02; C07D471/14; C07D487/04; C07D519/00
Domestic Patent References:
WO2015051341A12015-04-09
WO2014179154A22014-11-06
WO2012088314A12012-06-28
WO2014134776A12014-09-12
WO2014179154A22014-11-06
WO2014137728A12014-09-12
WO2015051314A22015-04-09
Foreign References:
JP2004203804A2004-07-22
US4352931A1982-10-05
Other References:
See also references of EP 3699179A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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