PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS

Title:

PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS

Document Type and Number:

WIPO Patent Application WO2005123692

Kind Code:

A8

Abstract:

The invention relates to new therapeutically useful pyridazin-3(2H)-one derivatives of Formula (I) and to pharmaceutical compositions containing them. These compounds are potent and selective inhibitors of phosphodiesterase 4 (PDE4) and are thus useful in the treatment, prevention or suppression of pathological conditions, diseases and disorders known to be susceptible of being improved by inhibition of PDE4 such as asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis or irritable bowel disease.

Inventors:

BUIL ALBERO MARIA ANTONIA (ES)
DAL PIAZ VITTORIO (IT)
GARRIDO RUBIO YOLANDA (ES)
GRACIA FERRER JORDI (ES)
PAGES SANTACANA LLUIS MIQUEL (ES)
TALTAVULL MOLL JOAN (ES)

Application Number:

PCT/EP2005/006304

Publication Date:

May 04, 2006

Filing Date:

June 13, 2005

Export Citation:

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Assignee:

ALMIRALL PRODESFARMA SA (ES)
BUIL ALBERO MARIA ANTONIA (ES)
DAL PIAZ VITTORIO (IT)
GARRIDO RUBIO YOLANDA (ES)
GRACIA FERRER JORDI (ES)
PAGES SANTACANA LLUIS MIQUEL (ES)
TALTAVULL MOLL JOAN (ES)

International Classes:

C07D237/24; C07D401/12; C07D401/14; C07D409/14; (IPC1-7): C07D237/24; C07D401/12; C07D401/14; C07D409/14; A61K31/50; A61K31/501; A61P11/16

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