Title:
PYRIDAZINE COMPOUNDS AND METHODS
Document Type and Number:
WIPO Patent Application WO2006050359
Kind Code:
A3
Abstract:
The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.
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Inventors:
WATTERSON D MARTIN (US)
VAN ELDIK LINDA (US)
HAIECH JACQUES (FR)
HIBERT MARCEL (FR)
BOURGUIGNON JEAN-JACQUES (FR)
VELENTZA ANASTASIA (US)
HU WENHUI (US)
ZASADZKI MAGDELENA (US)
VAN ELDIK LINDA (US)
HAIECH JACQUES (FR)
HIBERT MARCEL (FR)
BOURGUIGNON JEAN-JACQUES (FR)
VELENTZA ANASTASIA (US)
HU WENHUI (US)
ZASADZKI MAGDELENA (US)
Application Number:
PCT/US2005/039476
Publication Date:
August 10, 2006
Filing Date:
November 02, 2005
Export Citation:
Assignee:
UNIV NORTHWESTERN (US)
UNIV PASTEUR (FR)
WATTERSON D MARTIN (US)
VAN ELDIK LINDA (US)
HAIECH JACQUES (FR)
HIBERT MARCEL (FR)
BOURGUIGNON JEAN-JACQUES (FR)
VELENTZA ANASTASIA (US)
HU WENHUI (US)
ZASADZKI MAGDELENA (US)
UNIV PASTEUR (FR)
WATTERSON D MARTIN (US)
VAN ELDIK LINDA (US)
HAIECH JACQUES (FR)
HIBERT MARCEL (FR)
BOURGUIGNON JEAN-JACQUES (FR)
VELENTZA ANASTASIA (US)
HU WENHUI (US)
ZASADZKI MAGDELENA (US)
International Classes:
A01N43/58; A61K31/535; A01N43/60; A61K31/495; A61K31/50; C07D237/26; C07D237/36; C07D413/00; C07D487/00
Foreign References:
| US4977152A | 1990-12-11 |
Other References:
ALLEN C.F.H. ET AL.: "Some 3,4-Diphenylcinnolines and Related Compounds", JOURNAL OF THE AMERICAN SOCIETY, vol. 73, pages 5850 - 5856, XP002387357
CONTRERAS ET AL.: "Design Synthesis, and Structure-Activity Relationships of a Series of 3-[2-(1-Benzylpiperidin-4-yl)ethylamino]pyridazine Derivatives as Acetylcholinesterase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, 2001, pages 2707 - 2718, XP002353010
VELENTZA ET AL.: "An Aminopyridazine-Based Inhibitor of a Pro-Apoptotic Protein Kinase Attenuates Hypoxia-Ischemia Induced Acute Brain Injury", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, 2003, pages 3465 - 3470, XP003001904
CONTRERAS ET AL.: "Design Synthesis, and Structure-Activity Relationships of a Series of 3-[2-(1-Benzylpiperidin-4-yl)ethylamino]pyridazine Derivatives as Acetylcholinesterase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, 2001, pages 2707 - 2718, XP002353010
VELENTZA ET AL.: "An Aminopyridazine-Based Inhibitor of a Pro-Apoptotic Protein Kinase Attenuates Hypoxia-Ischemia Induced Acute Brain Injury", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, 2003, pages 3465 - 3470, XP003001904
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