Title:
PYRIDAZINE DERIVATIVES FOR INHIBITING HUMAN STEAROYL-COA-DESATURASE
Document Type and Number:
WIPO Patent Application WO2006034341
Kind Code:
A3
Abstract:
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where x, y, G, J, K, L, M, Q, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Inventors:
KAMBOJ RAJENDER (CA)
ZHANG ZAIHUI (CA)
FU JIAN-MIN (CA)
SVIRIDOV SERGUEI (CA)
CHOWDHURY SULTAN (CA)
KODUMURU VISHNUMURTHY (CA)
ZHANG ZAIHUI (CA)
FU JIAN-MIN (CA)
SVIRIDOV SERGUEI (CA)
CHOWDHURY SULTAN (CA)
KODUMURU VISHNUMURTHY (CA)
Application Number:
PCT/US2005/033820
Publication Date:
May 18, 2006
Filing Date:
September 20, 2005
Export Citation:
Assignee:
XENON PHARMACEUTICALS INC (CA)
KAMBOJ RAJENDER (CA)
ZHANG ZAIHUI (CA)
FU JIAN-MIN (CA)
SVIRIDOV SERGUEI (CA)
CHOWDHURY SULTAN (CA)
KODUMURU VISHNUMURTHY (CA)
KAMBOJ RAJENDER (CA)
ZHANG ZAIHUI (CA)
FU JIAN-MIN (CA)
SVIRIDOV SERGUEI (CA)
CHOWDHURY SULTAN (CA)
KODUMURU VISHNUMURTHY (CA)
International Classes:
A61P3/06; A61K31/501; A61P3/10; A61P43/00; C07D237/24
Domestic Patent References:
| WO2005011654A2 | 2005-02-10 | |||
| WO2005011655A2 | 2005-02-10 | |||
| WO2005011656A2 | 2005-02-10 | |||
| WO2005011657A2 | 2005-02-10 |
Other References:
COHEN, P; NTAMBI, J M; FRIEDMAN, J M: "Stearoyl-CoA desaturase-1 and the metabolic syndrome", CURRENT DRUG TARGETS: IMMUNE, ENDOCRINE AND METABOLIC DISORDERS, vol. 3, no. 4, 2003, pages 271 - 280, XP009063585
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