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Patent Searching and Data


Title:
PYRIDAZINONES AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/055966
Kind Code:
A3
Abstract:
Disclosed are compounds according to Formula (A), and related tautomers and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (A).

Inventors:
YU MAOLIN (US)
DANIELS MATTHEW (US)
HARMANGE JEAN-CHRISTOPHE (US)
TIBBITTS THOMAS (US)
LEDEBOER MARK (US)
WALSH LIRON (US)
MUNDEL PETER (US)
MALOJCIC GORAN (US)
Application Number:
PCT/US2018/051465
Publication Date:
April 18, 2019
Filing Date:
September 18, 2018
Export Citation:
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Assignee:
GOLDFINCH BIO INC (US)
International Classes:
A61K31/50; C07D237/16; C07D237/22
Domestic Patent References:
WO2017197051A12017-11-16
WO2014058747A12014-04-17
Foreign References:
US20050176722A12005-08-11
US20070287696A12007-12-13
US20080027041A12008-01-31
Other References:
STRAPPAGHETTI ET AL.: "Adenosine receptors: synthesis, structure-activity relationships and biological activity of new 6-amino purine derivatives", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, 8 February 1999 (1999-02-08), pages 501 - 508, XP026884003, DOI: doi:10.1016/S0223-5234(98)80050-0
DATABASE PubChem U.S. National Library of Medicine; 21 June 2015 (2015-06-21), "4-Chloro-5-[4-(4-methoxyphenoxy)piperidin-1 -yl]-2,3-dihydropyridazin-3-one", XP055592422, retrieved from NCBI Database accession no. 45834084
DATABASE PubChem Compound U.S. National Library of Medicine; 7 February 2015 (2015-02-07), "LNRUODMAEBORIK-UHFFFAOYSA-N", XP055592427, retrieved from NCBI Database accession no. 86805598
CASTLE ET AL.: "Pyridazines. III. The synthesis of substituted pyridazines", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 2, December 1965 (1965-12-01), pages 463 - 472, XP009098015, DOI: doi:10.1002/jhet.5570020427
DATABASE PubChem compound U.S. National Library of Medicine; 12 July 2014 (2014-07-12), "4-Chloro-2-phenyl-5-{5H,6H,7H,8H- pyrido[3,4-d]pyrimidin-7-yl}-2,3-dihydropyridazin-3-one", XP055592432, Database accession no. 75420213
DATABASE Pubchem compound U.S. National Library of Medicine; 7 February 2015 (2015-02-07), "YDHFXQRLHBDRHD-UHFFFAOYSA-N", XP055592434, retrieved from NCBI Database accession no. 86942850
Attorney, Agent or Firm:
GORDON, Dana, M. et al. (US)
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