Title:
PYRIDINE-2-AMINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/143985
Kind Code:
A1
Abstract:
Disclosed in the present invention are a pyridine-2-amine derivative and a pharmaceutical composition and use thereof. The pyridine-2-amine derivative can be used as a TLR8 selective agonist, has the characteristics of high selectivity, strong activity and high safety, can be used for preventing and/or treating diseases related to TLR activity, for example, diseases caused by or related to pathogen infection, immunological diseases, inflammation, and tumors, can also be used for preparing a vaccine adjuvant to enhance immune response, and has better application prospects and research and development value.
Inventors:
LIAO XUEBIN (CN)
WANG ZHISONG (CN)
ZHANG YAN (CN)
WANG ZHISONG (CN)
ZHANG YAN (CN)
Application Number:
PCT/CN2021/143703
Publication Date:
July 07, 2022
Filing Date:
December 31, 2021
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
BEIJING YUFAN BIOTECHNOLOGIES CO LTD (CN)
BEIJING YUFAN BIOTECHNOLOGIES CO LTD (CN)
International Classes:
C07D471/04; A61K31/435; A61K31/4375; A61P5/00; A61P35/00; A61P37/04; C07D227/10
Domestic Patent References:
| WO2021071821A1 | 2021-04-15 | |||
| WO2021178488A1 | 2021-09-10 | |||
| WO2020198026A1 | 2020-10-01 | |||
| WO2009049421A1 | 2009-04-23 | |||
| WO2010088177A1 | 2010-08-05 |
Foreign References:
| CN101516369A | 2009-08-26 | |||
| US20060128669A1 | 2006-06-15 | |||
| CN102026970A | 2011-04-20 | |||
| CN109776335A | 2019-05-21 | |||
| CN102834380A | 2012-12-19 | |||
| CN109438343A | 2019-03-08 |
Other References:
CAI, ZHONGJIAN ET AL.: "Copper-Catalyzed Cyclization of Oxime Acetates with 2-Benzylidenemalononitriles for Synthesis of 2-Aminonicotinonitriles", ACTA CHIMICA SINICA, vol. 72, no. 8, 15 August 2014 (2014-08-15), pages 914 - 919, XP055947127
KOWALSKI PIOTR: "Electrophilic benzylation of 2-aminopyridine ring", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 28, no. 4, 31 July 1991 (1991-07-31), pages 875 - 879, XP055947182
S.M. BIRGE ET AL., J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
KOWALSKI PIOTR: "Electrophilic benzylation of 2-aminopyridine ring", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 28, no. 4, 31 July 1991 (1991-07-31), pages 875 - 879, XP055947182
S.M. BIRGE ET AL., J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
Attorney, Agent or Firm:
BEIJING IPLING INTELLECTUAL PROPERTY LAW FIRM (CN)
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