Title:
PYRIDINE-3-CARBOXYAMIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2010/061971
Kind Code:
A1
Abstract:
Provided is a novel JAK3 inhibitor useful as a preventive and/or therapeutic agent for organ transplant rejection, graft versus host disease (GvHD), rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjogren’s syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic conjunctivitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia, etc. A pyridine-3-carboxyamide derivative represented by general formula (1) or a salt thereof or a solvate thereof.
Inventors:
KITAMURA TAKAHIRO (JP)
YAMADA HAJIME (JP)
TAKEMURA SHUNJI (JP)
ASHIKAWA MASANORI (JP)
ISHIKAWA TETSUYA (JP)
MIYAKE YOSHIHARU (JP)
KOUKETSU AKIYASU (JP)
SATO SEIICHI (JP)
ISHIWATA HIROYUKI (JP)
TABUNOKI YUICHIRO (JP)
SHIBASAKI MANABU (JP)
OZAWA TAKATOSHI (JP)
SHIGEMI RYOTA (JP)
DOI TAKESHI (JP)
TAMURA MASAHIRO (JP)
YAMADA HAJIME (JP)
TAKEMURA SHUNJI (JP)
ASHIKAWA MASANORI (JP)
ISHIKAWA TETSUYA (JP)
MIYAKE YOSHIHARU (JP)
KOUKETSU AKIYASU (JP)
SATO SEIICHI (JP)
ISHIWATA HIROYUKI (JP)
TABUNOKI YUICHIRO (JP)
SHIBASAKI MANABU (JP)
OZAWA TAKATOSHI (JP)
SHIGEMI RYOTA (JP)
DOI TAKESHI (JP)
TAMURA MASAHIRO (JP)
Application Number:
PCT/JP2009/070363
Publication Date:
June 03, 2010
Filing Date:
November 27, 2009
Export Citation:
Assignee:
KOWA CO (JP)
KITAMURA TAKAHIRO (JP)
YAMADA HAJIME (JP)
TAKEMURA SHUNJI (JP)
ASHIKAWA MASANORI (JP)
ISHIKAWA TETSUYA (JP)
MIYAKE YOSHIHARU (JP)
KOUKETSU AKIYASU (JP)
SATO SEIICHI (JP)
ISHIWATA HIROYUKI (JP)
TABUNOKI YUICHIRO (JP)
SHIBASAKI MANABU (JP)
OZAWA TAKATOSHI (JP)
SHIGEMI RYOTA (JP)
DOI TAKESHI (JP)
TAMURA MASAHIRO (JP)
KITAMURA TAKAHIRO (JP)
YAMADA HAJIME (JP)
TAKEMURA SHUNJI (JP)
ASHIKAWA MASANORI (JP)
ISHIKAWA TETSUYA (JP)
MIYAKE YOSHIHARU (JP)
KOUKETSU AKIYASU (JP)
SATO SEIICHI (JP)
ISHIWATA HIROYUKI (JP)
TABUNOKI YUICHIRO (JP)
SHIBASAKI MANABU (JP)
OZAWA TAKATOSHI (JP)
SHIGEMI RYOTA (JP)
DOI TAKESHI (JP)
TAMURA MASAHIRO (JP)
International Classes:
A61K31/44; C07D213/82; A61K31/4439; A61K31/4545; A61K31/496; A61K31/506; A61K31/5377; A61K31/551; A61P1/04; A61P3/10; A61P5/14; A61P7/04; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P27/02; A61P27/16; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D401/12; C07D401/14; C07D405/12; C07D413/12; C07D417/12
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| WO2007062459A1 | 2007-06-07 | |||
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| WO2006133426A2 | 2006-12-14 | |||
| WO2007062459A1 | 2007-06-07 |
Foreign References:
| US20060217417A1 | 2006-09-28 |
Other References:
NAGASHIMA,S. ET AL.: "Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl) amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, no. ISS.13, 1 July 2008 (2008-07-01), pages 6509 - 6521, XP022711156, DOI: doi:10.1016/j.bmc.2008.05.031
GENE, vol. 285, 2002, pages 1 - 24
CURR. PHARM. DESIGN., vol. 10, 2004, pages 1767 - 1784
J. IMMUNOL., vol. 163, 1999, pages 5411 - 5417
J. BIOL. CHEM., vol. 276, 2001, pages 25378 - 25385
NATURE, vol. 377, 1995, pages 65 - 68
SCIENCE, vol. 266, 1994, pages 1042 - 1045
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 257, 1999, pages 807 - 813
BIOORG. MED. CHEM. LETT., vol. 17, 2007, pages 1250 - 1253
BIOORG. MED. CHEM. LETT., vol. 13, 2003, pages 3105 - 3110
BIOORG. MED. CHEM. LETT., vol. 17, 2007, pages 326 - 31
LETT., vol. 8, 2006, pages 5609 - 5612
JOHN F. HARTWIG ET AL., J. AM CHEM. SOC., vol. 118, 1996, pages 7217 - 7218
MIYAURA, N., SUZUKI, A., CHEM. REV., vol. 95, 1995, pages 2457 - 2483
Y. -J. CHEN, H. - H. CHEN, ORG. LETT., vol. 8, 2006, pages 5609 - 5612
"Chemical Experiment Series, Vol. 15, Oxidation and Reduction (II", vol. 15, 1991, MARUZEN
"Protective Groups in Organic Synthesis", 1990, JOHN WILEY & SONS PUB., pages: 309 - 385
R.F. BORCH, M.D. BERNSTEIN, H.D. DURST, J. AM CHEM. SOC., vol. 93, 1971, pages 2897 - 2904
AHMED F. ABDEL-MAGID, CYNTHIA A. MARYANOFF, TETRAHEDRON LETT., vol. 31, 1990, pages 5595 - 5598
R. APODACA, W. XIAO, ORG. LETT., vol. 3, 2001, pages 1745 - 1748
H. KATO, I. SHIBATA, S. YASAKA, S. TSUNOI, M. YASUDA, A. BABA, CHEM. COMMUN., 2006, pages 4189 - 4191
"Chemical Experiment Series, Vol. 21, Organic Synthesis Reaction III", vol. 21, 1991, pages: 196 - 238
See also references of EP 2380877A4
GENE, vol. 285, 2002, pages 1 - 24
CURR. PHARM. DESIGN., vol. 10, 2004, pages 1767 - 1784
J. IMMUNOL., vol. 163, 1999, pages 5411 - 5417
J. BIOL. CHEM., vol. 276, 2001, pages 25378 - 25385
NATURE, vol. 377, 1995, pages 65 - 68
SCIENCE, vol. 266, 1994, pages 1042 - 1045
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 257, 1999, pages 807 - 813
BIOORG. MED. CHEM. LETT., vol. 17, 2007, pages 1250 - 1253
BIOORG. MED. CHEM. LETT., vol. 13, 2003, pages 3105 - 3110
BIOORG. MED. CHEM. LETT., vol. 17, 2007, pages 326 - 31
LETT., vol. 8, 2006, pages 5609 - 5612
JOHN F. HARTWIG ET AL., J. AM CHEM. SOC., vol. 118, 1996, pages 7217 - 7218
MIYAURA, N., SUZUKI, A., CHEM. REV., vol. 95, 1995, pages 2457 - 2483
Y. -J. CHEN, H. - H. CHEN, ORG. LETT., vol. 8, 2006, pages 5609 - 5612
"Chemical Experiment Series, Vol. 15, Oxidation and Reduction (II", vol. 15, 1991, MARUZEN
"Protective Groups in Organic Synthesis", 1990, JOHN WILEY & SONS PUB., pages: 309 - 385
R.F. BORCH, M.D. BERNSTEIN, H.D. DURST, J. AM CHEM. SOC., vol. 93, 1971, pages 2897 - 2904
AHMED F. ABDEL-MAGID, CYNTHIA A. MARYANOFF, TETRAHEDRON LETT., vol. 31, 1990, pages 5595 - 5598
R. APODACA, W. XIAO, ORG. LETT., vol. 3, 2001, pages 1745 - 1748
H. KATO, I. SHIBATA, S. YASAKA, S. TSUNOI, M. YASUDA, A. BABA, CHEM. COMMUN., 2006, pages 4189 - 4191
"Chemical Experiment Series, Vol. 21, Organic Synthesis Reaction III", vol. 21, 1991, pages: 196 - 238
See also references of EP 2380877A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
Atsushi Aoki (JP)
Atsushi Aoki (JP)
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