Title:
PYRIDINE COMPOUND SUBSTITUTED BY HETEROARYL
Document Type and Number:
WIPO Patent Application WO/2020/162612
Kind Code:
A1
Abstract:
The present invention provides a compound represented by formula (I'), which has an inhibitory effect on an enzyme that produces 20-HETE, or a pharmaceutically acceptable salt of the compound. (In formula (I'), ring D represents one of the groups represented by formula (I'-1) to formula (I'-3); each of R1, R2, R3 and R4 independently represents a hydrogen atom, a fluorine atom, a methyl group or the like; X represents -O-, -S- or -CH2-; and R5 represents one of the structures represented by formulae (II).)
Inventors:
KAWAMURA MADOKA (JP)
FUNAYAMA KOSUKE (JP)
SUZUKI KAZUAKI (JP)
TANAKA HIROAKI (JP)
FUNAYAMA KOSUKE (JP)
SUZUKI KAZUAKI (JP)
TANAKA HIROAKI (JP)
Application Number:
PCT/JP2020/004894
Publication Date:
August 13, 2020
Filing Date:
February 07, 2020
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D401/04; A61K31/4439; A61K31/444; A61K31/46; A61K31/497; A61K31/506; A61K31/5377; A61P13/12; A61P43/00; C07D401/14; C07D405/14; C07D409/14; C07D417/14
Domestic Patent References:
| WO2017141927A1 | 2017-08-24 | |||
| WO2003022821A1 | 2003-03-20 | |||
| WO2019031618A1 | 2019-02-14 |
Foreign References:
| JP2004262890A | 2004-09-24 | |||
| JP2019034932A | 2019-03-07 |
Other References:
NAKAMURA, T ET AL.: "Pyrazole and Isoxazole Derivatives as New, Potent, and Selective 20- Hydroxy-5,8,11,14-eicosatetraenoic Acid Synthase Inhibitors", J. MED. CHEM., vol. 1, no. 46, 2003, pages 5416 - 5427, XP009143338
Attorney, Agent or Firm:
YAMAMOTO, Osamu et al. (JP)
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