PYRIDINE DERIVATIVE HAVING TTK INHIBITION ACTIVITY

WIPO Patent Application WO/2010/007756

A1

The object aims to provide an effective inhibitor of TTK protein kinase and an effective anti-cancer agent.  The object can be achieved by a compound of the invention and inventions related to the compound (e.g., a pharmaceutical composition, a TTK inhibitor).  A novel series of compounds having specific properties which are particularly useful for the preparation of a medicinal product for inhibiting the activity of TTK kinase to treat the diseases can be successfully found.  Particularly, the compound is useful for the treatment of proliferative diseases (e.g., cancer) which occur in the form of a solid tumor or a hematologic tumor and in which it is known that TTK kinase is active.  The compound is particularly useful for diseases including colorectal cancer, breast cancer, lung cancer, prostate cancer, pancreatic cancer, bladder cancer, renal cancer, leukemia, lymphoma and others.

KUSAKABE KEN-ICHI (JP)
IDE NOBUYUKI (JP)
TADANO GENTA (JP)
FUJIOKA MASAHIKO (JP)
TAGASHIRA SACHIE (JP)
TACHIBANA YUKI (JP)
ENDOH TAKESHI (JP)
ISHIZUKA NATSUKI (JP)
KOJIMA EIICHI (JP)
YAMAGUCHI NAOKO (JP)

PCT/JP2009/003276

January 21, 2010

July 13, 2009

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SHIONOGI & CO (JP)
KUSAKABE KEN-ICHI (JP)
IDE NOBUYUKI (JP)
TADANO GENTA (JP)
FUJIOKA MASAHIKO (JP)
TAGASHIRA SACHIE (JP)
TACHIBANA YUKI (JP)
ENDOH TAKESHI (JP)
ISHIZUKA NATSUKI (JP)
KOJIMA EIICHI (JP)
YAMAGUCHI NAOKO (JP)

C07D213/74; A61K31/435; A61K31/44; A61K31/4409; A61K31/4418; A61K31/443; A61K31/4433; A61K31/4436; A61K31/4439; A61K31/444; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/496; A61K31/497; A61K31/498; A61K31/4985; A61K31/501; A61K31/506; A61K31/5377; A61K31/55; A61K31/551; A61K31/695; A61P9/00; A61P11/06; A61P17/00; A61P19/02; A61P29/00; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P37/08; A61P43/00; C07D213/85; C07D221/06; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D405/04; C07D405/12; C07D405/14; C07D409/04; C07D409/12; C07D409/14; C07D413/04; C07D413/12; C07D413/14; C07D417/04; C07D417/12; C07D417/14; C07D487/04; C07F7/10

WO2007018319A1	2007-02-15
WO2006118231A1	2006-11-09
WO2007124546A1	2007-11-08
WO2009032703A1	2009-03-12

JP2002114777A	2002-04-16
US20060173050A1	2006-08-03
JP2006519760A	2006-08-31
JP2004526716A	2004-09-02

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YAMAMOTO, Shusaku et al. (JP)
Shusaku Yamamoto (JP)

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