Title:
PYRIDINE DERIVATIVE AND MEDICINE
Document Type and Number:
WIPO Patent Application WO/2014/034898
Kind Code:
A1
Abstract:
The main purpose of the invention is to provide a novel pyridine derivative or a pharmaceutically acceptable salt thereof. Examples of the invention include a pyridine derivative represented by general formula [1], and a pharmaceutically acceptable salt thereof. This compound or a pharmaceutically acceptable salt thereof exhibits mGluR5 inhibitory activity, and can therefore be used as an agent for the prevention or treatment of, e.g., pain (for example, acute pain, chronic pain, inflammatory pain, neuropathic pain, hyperalgesia, thermal hyperalgesia, allodynia, pain due to noxious thermal stimulation, pain due to noxious mechanical stimulation, pain in the lower urinary tract or reproductive organs, or migraine), pruritus, lower urinary tract symptoms or lower urinary tract disorders, gastroesophageal reflux disease (GERD), gastroesophageal reflux associated with transient lower esophageal sphincter relaxation (TLESR), and diseases of the central nervous system.
Inventors:
TSUJI TAKASHI (JP)
SHIRAI MASAAKI (JP)
SHIRAI MASAAKI (JP)
Application Number:
PCT/JP2013/073438
Publication Date:
March 06, 2014
Filing Date:
August 30, 2013
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
International Classes:
C07D401/04; A61K31/4709; A61K31/497; A61K31/506; A61P1/04; A61P1/16; A61P3/04; A61P3/10; A61P13/02; A61P13/10; A61P17/04; A61P25/00; A61P25/06; A61P25/14; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/36; A61P29/00; A61P35/00; C07D401/12; C07D401/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14
Domestic Patent References:
| WO2012092530A1 | 2012-07-05 | |||
| WO2009047255A1 | 2009-04-16 | |||
| WO2006035061A1 | 2006-04-06 | |||
| WO2009014637A2 | 2009-01-29 | |||
| WO2007000582A1 | 2007-01-04 |
Foreign References:
| JP2007524710A | 2007-08-30 | |||
| JP2009535307A | 2009-10-01 | |||
| JP2012131829A | 2012-07-12 | |||
| US20050038052A1 | 2005-02-17 | |||
| US20060293364A1 | 2006-12-28 | |||
| US20030187026A1 | 2003-10-02 |
Other References:
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CELL, vol. 146, 2011, pages 785 - 798
NEUROSCIENCE LETTERS, vol. 361, 2004, pages 220 - 224
NEUROPHARMACOLOGY, vol. 40, 2001, pages 10 - 19
EXPERT OPIN. THER. TARGETS, vol. 6, no. 3, 2002, pages 349 - 361
PSYCHOPHARMACOLOGY, vol. 179, 2005, pages 207 - 217
CURRENT DRUG TARGETS-CNS & NEUROLOGICAL DISORDERS, vol. 1, 2002, pages 283 - 296
EXPERT OPIN INVESTIG DRUGS, vol. 19, no. 4, 2010, pages 555 - 561
MOLECULAR PAIN, vol. 8, no. 20, 2012
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PHARMACOL. REV., vol. 63, 2011, pages 35 - 58
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J. PHYSIOL., vol. 586, no. 6, 2008, pages 1503 - 1508
CNS NEUROL DISORD DRUG TARGETS, vol. 8, no. 6, 2009, pages 475 - 491
BRAIN RES., vol. 1019, no. 1-2, 2004, pages 246 - 254
NEUROSCIENCE LETTERS, vol. 420, 2007, pages 155 - 159
NEUROPSYCHOPHARMACOLOGY, vol. 29, 2004, pages 921 - 928
PSYCHOPHARMACOLOGY, vol. 225, 2013, pages 151 - 159
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BIOCHIMIE., vol. 94, no. 11, 2012, pages 2366 - 2375
BJU INTERNATIONAL, vol. 102, 2008, pages 890 - 898
L.W.CROCK ET AL.: "MGluR5 is necessary for the full expression of both inflammatory and non-inflammatory bladder pain", NEUROSCIENCE 2011, PROGRAM NO. 180.08/POSTER NO. 0021, 2011, Retrieved from the Internet
JOURNAL OF ORGANIC CHEMISTRY, vol. 56, 1991, pages 6199 - 6205
ORGANIC MASS SPECTROMETRY, vol. 23, 1988, pages 719 - 722
CANADIAN JOURNAL OF CHEMISTRY, vol. 75, 1997, pages 965 - 974
HELVETICA CHIMICA ACTA, vol. 28, 1945, pages 1684 - 1690
HELVETICA CHIMICA ACTA, vol. 27, 1944, pages 1854 - 1858
"Oxidation Reaction", vol. 23, 1991, MARUZEN, article "Dai 4-han Jikken Kagaku Kouza", pages: 37 - 78,299-3
TETRAHEDRON, vol. 34, 1978, pages 1651 - 1660
TETRAHEDRON LETTERS, vol. 35, 1994, pages 8019 - 8022
ORGANIC REACTIONS, vol. 14, 1965, pages 270
TETRAHEDRON, vol. 65, 2009, pages 8969 - 8980
EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 676, 2012, pages 75 - 80
See also references of EP 2891656A4
CELL, vol. 146, 2011, pages 785 - 798
NEUROSCIENCE LETTERS, vol. 361, 2004, pages 220 - 224
NEUROPHARMACOLOGY, vol. 40, 2001, pages 10 - 19
EXPERT OPIN. THER. TARGETS, vol. 6, no. 3, 2002, pages 349 - 361
PSYCHOPHARMACOLOGY, vol. 179, 2005, pages 207 - 217
CURRENT DRUG TARGETS-CNS & NEUROLOGICAL DISORDERS, vol. 1, 2002, pages 283 - 296
EXPERT OPIN INVESTIG DRUGS, vol. 19, no. 4, 2010, pages 555 - 561
MOLECULAR PAIN, vol. 8, no. 20, 2012
J. PHYSIOL., vol. 589, no. 23, 2011, pages 5833 - 5843
PHARMACOL. REV., vol. 63, 2011, pages 35 - 58
NEUROSCIENCE LETTERS, vol. 450, 2009, pages 12 - 17
J. NEURAL TRANSM., vol. 118, 2011, pages 1703 - 1716
NEUROPHARMACOLOGY, vol. 44, 2003, pages 562 - 572
J. NEURAL. TRANSM., vol. 115, 2008, pages 1609 - 1619
PLOS BIOL., vol. 5, no. 3, March 2007 (2007-03-01), pages E52
J. PHYSIOL., vol. 586, no. 6, 2008, pages 1503 - 1508
CNS NEUROL DISORD DRUG TARGETS, vol. 8, no. 6, 2009, pages 475 - 491
BRAIN RES., vol. 1019, no. 1-2, 2004, pages 246 - 254
NEUROSCIENCE LETTERS, vol. 420, 2007, pages 155 - 159
NEUROPSYCHOPHARMACOLOGY, vol. 29, 2004, pages 921 - 928
PSYCHOPHARMACOLOGY, vol. 225, 2013, pages 151 - 159
J. PHARMACOL. EXP. THER., vol. 313, 2005, pages 395 - 402
BIOCHIMIE., vol. 94, no. 11, 2012, pages 2366 - 2375
BJU INTERNATIONAL, vol. 102, 2008, pages 890 - 898
L.W.CROCK ET AL.: "MGluR5 is necessary for the full expression of both inflammatory and non-inflammatory bladder pain", NEUROSCIENCE 2011, PROGRAM NO. 180.08/POSTER NO. 0021, 2011, Retrieved from the Internet
JOURNAL OF ORGANIC CHEMISTRY, vol. 56, 1991, pages 6199 - 6205
ORGANIC MASS SPECTROMETRY, vol. 23, 1988, pages 719 - 722
CANADIAN JOURNAL OF CHEMISTRY, vol. 75, 1997, pages 965 - 974
HELVETICA CHIMICA ACTA, vol. 28, 1945, pages 1684 - 1690
HELVETICA CHIMICA ACTA, vol. 27, 1944, pages 1854 - 1858
"Oxidation Reaction", vol. 23, 1991, MARUZEN, article "Dai 4-han Jikken Kagaku Kouza", pages: 37 - 78,299-3
TETRAHEDRON, vol. 34, 1978, pages 1651 - 1660
TETRAHEDRON LETTERS, vol. 35, 1994, pages 8019 - 8022
ORGANIC REACTIONS, vol. 14, 1965, pages 270
TETRAHEDRON, vol. 65, 2009, pages 8969 - 8980
EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 676, 2012, pages 75 - 80
See also references of EP 2891656A4
Attorney, Agent or Firm:
MASUI, Yasushi (JP)
Yasushi Masui (JP)
Yasushi Masui (JP)
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