Title:
PYRIDINE DERIVATIVES FOR INHIBITING HUMAN STEAROYL-COA-DESATURASE
Document Type and Number:
WIPO Patent Application WO2006034446
Kind Code:
A3
Abstract:
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I), where x, y, G, J, K, L, M, W, V, R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Inventors:
KAMBOJ RAJENDER (CA)
KODUMURU VISHNUMURTHY (CA)
KODUMURU VISHNUMURTHY (CA)
Application Number:
PCT/US2005/034136
Publication Date:
May 26, 2006
Filing Date:
September 20, 2005
Export Citation:
Assignee:
XENON PHARMACEUTICALS INC (CA)
ROTH CAROL J (US)
KAMBOJ RAJENDER (CA)
KODUMURU VISHNUMURTHY (CA)
ROTH CAROL J (US)
KAMBOJ RAJENDER (CA)
KODUMURU VISHNUMURTHY (CA)
International Classes:
A61K31/496; A61P3/06; A61P3/10; A61P43/00; C07D295/18
Domestic Patent References:
| WO2005011654A2 | 2005-02-10 | |||
| WO2005011655A2 | 2005-02-10 | |||
| WO2005011656A2 | 2005-02-10 | |||
| WO2005011657A2 | 2005-02-10 |
Other References:
COHEN, P; NTAMBI, J M; FRIEDMAN, J M: "Stearoyl-CoA desaturase-1 and the metabolic syndrome", CURENT DRUG TARGETS: IMMUNE, ENDOCRINE AND METABOLIC DISORDERS, vol. 3, no. 4, 2003, pages 271 - 280, XP009063538
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