PYRIDINE DERIVATIVES - TAISHO PHARMACEUTICAL CO LTD

Title:

PYRIDINE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/1996/016942

Kind Code:

A1

Abstract:

Pyridine derivatives represented by general formula (I) or salts thereof are expected to act on neurons in vivo directly or indirectly to exhibit the effects of ameliorating and curing neuropathy accompanying nerve degeneration. In said formula, R1 represents methyl or any of the functional groups represented by the following formulae: -CONHCH2CH2N(CH3)2, -CONHCH2CH2CH2N(CH3)2, -COOCH2CH2N(CH3)2, -COOCH2CH2N(CH2CH3)2, -NHCOCH2N(CH3)2, -NHCOCH2N(CH2CH3)2, and R2 represents hydrogen, amino or any of the functional groups represented by the following formulae: -CONHCH2CH2N(CH3)2, (b), -COOCH2CH2N(CH3)2, -NHCOCH2H(CH3)2, -NHCOCH2N(CH2CH3)2. For example, they can be used as ameliorants and remedies for symptoms and diseases accompanying traumatic, drug-induced (by, e.g., alcohol or antineoplastic agent), inflammatory, metabolic (as observed in, e.g., diabetes), and idiopathic peripheral nerve degenerations. They are also usable as ameliorants and remedies for symptoms and diseases accompanying central nerve degeneration, for example, senile dementia of Alzheimer type, cerebrovascular dementia, Down's syndrome, Parkinson's disease, Huntington's chorea, sequelae of cerebral ischemia, cerebral infarction, cerebral hemorrhage and head injury, amnesia and spinal neuroparalysis.

Inventors:

SHIRAI HIROFUSA (JP)
HANABUSA KENJI (JP)
TAKAHASHI YUKI (JP)
MIZOBE FUMIO (JP)
HANADA KAZUNORI (JP)

Application Number:

PCT/JP1995/002399

Publication Date:

June 06, 1996

Filing Date:

November 27, 1995

Export Citation:

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Assignee:

TAISHO PHARMACEUTICAL CO LTD (JP)
SHIRAI HIROFUSA (JP)
HANABUSA KENJI (JP)
TAKAHASHI YUKI (JP)
MIZOBE FUMIO (JP)
HANADA KAZUNORI (JP)

International Classes:

C07D213/38; C07D213/40; C07D213/55; C07D213/56; (IPC1-7): C07D213/55; C07D213/56; C07D213/40; A61K31/44

Domestic Patent References:

WO1994027604A1	1994-12-08
WO1994014440A1	1994-07-07

Other References: