Title:
PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS
Document Type and Number:
WIPO Patent Application WO2004046113
Kind Code:
A3
Abstract:
PDE4 inhibition is achieved by novel nitroxide compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formulas I-III: wherein A, B, D, R<1>, R<2> , R<3> , R<7>, R<8>, R<9>, R<10 >and R<6> are as defined herein.
Inventors:
SCHUMACHER RICHARD A (US)
GRAHAM ELIZABETH DOORLY (US)
HOPPER ALLEN T (US)
TEHIM ASHOK (US)
GRAHAM ELIZABETH DOORLY (US)
HOPPER ALLEN T (US)
TEHIM ASHOK (US)
Application Number:
PCT/US2003/036986
Publication Date:
March 24, 2005
Filing Date:
November 19, 2003
Export Citation:
Assignee:
MEMORY PHARM CORP (US)
SCHUMACHER RICHARD A (US)
GRAHAM ELIZABETH DOORLY (US)
HOPPER ALLEN T (US)
TEHIM ASHOK (US)
SCHUMACHER RICHARD A (US)
GRAHAM ELIZABETH DOORLY (US)
HOPPER ALLEN T (US)
TEHIM ASHOK (US)
International Classes:
A61P25/16; A61P25/18; A61P25/28; C07D213/24; C07D213/89; C07D401/06; C07D401/12; C07D405/12; (IPC1-7): C07D213/89; C07D405/14; C07D405/12; C07D401/12; A61K31/4427; A61K31/4425; A61P25/16; A61P25/28; A61P25/18
Domestic Patent References:
| WO2002074726A2 | 2002-09-26 | |||
| WO2000050402A1 | 2000-08-31 | |||
| WO1995004046A1 | 1995-02-09 | |||
| WO1995020578A1 | 1995-08-03 | |||
| WO2004009552A1 | 2004-01-29 |
Other References:
MARTIN T J: "PDE4 INHIBITORS - A REVIEW OF THE RECENT PATENT LITERATURE", IDRUGS, CURRENT DRUGS LTD, GB, vol. 4, no. 3, 2001, pages 312 - 338, XP008006266, ISSN: 1369-7056
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