Title:
PYRIDINE THIO DERIVATIVE, AND PHARMACEUTICAL COMPOSITION WHICH CONTAINS SAME AND HAS ANTI-HELICOBACTER PYLORI ACTION
Document Type and Number:
WIPO Patent Application WO/2010/116740
Kind Code:
A1
Abstract:
Disclosed are a novel pyridine thio derivative, and a pharmaceutical composition using the novel pyridine thio derivative, particularly a pharmaceutical composition having selective antibacterial activity against Helicobacter pylori.
Specifically disclosed is a pyridine thio derivative represented by general formula (I) (wherein R1 and R2 each represents a hydrogen atom, a C1-8 alkyl group or the like; R3 and R4 each represents a hydrogen atom, a C1-8 alkyl group or the like; X represents -O-, -S- or the like; Y represents a C1-12 alkyl group which may be substituted by a substituent or -(R5-O)n-R6 (wherein R5 represents a C1-5 alkylene group; R6 represents a C1-8 alkyl group which may be substituted by a substituent, and n represents an integer of 1-10); and Z represents a hydrogen atom or the like), or a pharmacologically acceptable salt thereof. Also specifically disclosed is a pharmaceutical composition containing the pyridine thio derivative or a salt thereof.
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Inventors:
YAMAMOTO MASAICHI (JP)
ITO MASAHARU (JP)
TSUJII MASAHIKO (JP)
HAMAZAKI MITSUNORI (JP)
ITO MASAHARU (JP)
TSUJII MASAHIKO (JP)
HAMAZAKI MITSUNORI (JP)
Application Number:
PCT/JP2010/002561
Publication Date:
October 14, 2010
Filing Date:
April 08, 2010
Export Citation:
Assignee:
ARIGEN PHARMACEUTICALS INC (JP)
YAMAMOTO MASAICHI (JP)
ITO MASAHARU (JP)
TSUJII MASAHIKO (JP)
HAMAZAKI MITSUNORI (JP)
YAMAMOTO MASAICHI (JP)
ITO MASAHARU (JP)
TSUJII MASAHIKO (JP)
HAMAZAKI MITSUNORI (JP)
International Classes:
C07D401/12; A61K31/4439; A61P1/04; A61P31/04; A61P35/00
Domestic Patent References:
| WO2008075462A1 | 2008-06-26 | |||
| WO1996006825A1 | 1996-03-07 | |||
| WO1997023207A1 | 1997-07-03 | |||
| WO2008075462A1 | 2008-06-26 |
Foreign References:
| JPH05247035A | 1993-09-24 | |||
| JPH03173817A | 1991-07-29 | |||
| JPS6150979A | 1986-03-13 | |||
| JPS5839622A | 1983-03-08 | |||
| JPH02209809A | 1990-08-21 | |||
| JPH03173817A | 1991-07-29 | |||
| JPH0348680A | 1991-03-01 | |||
| JPH0769888A | 1995-03-14 | |||
| JPH05247035A | 1993-09-24 | |||
| JPS6150979A | 1986-03-13 | |||
| JPS5839622A | 1983-03-08 |
Other References:
RODINOVSKAYA, LA. ET AL.: "One-Pot Synthesis of Diverse 4-Di(tri)fluoromethyl-3- cyanopyridine-2(lH)-thiones and Their Utilities in the Cascade Synthesis of Annulated Heterocycles", J. COMB. CHEM., vol. 10, no. 2, 2008, pages 313 - 322, XP008167482
MARTIN J. BLASER, CLIN. INFECTIOUS DISEASE, vol. 15, 1992, pages 386 - 393
GRAHAM D.Y. ET AL., ANN. INTERN. MED., vol. 116, 1992, pages 705 - 708
ISMAIL, M. M. ET AL., CHEM PAPERS, vol. 58, no. 2, 2004, pages 117 - 125
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 141: 366111
KAIGORODOVES, E. A. ET AL., CHEM. HETER. COMPD., vol. 33, no. 6, 1997, pages 752 - 753
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 128: 127976
See also references of EP 2420500A4
MARTIN J. BLASER, CLIN. INFECTIOUS DISEASE, vol. 15, 1992, pages 386 - 393
GRAHAM D.Y. ET AL., ANN. INTERN. MED., vol. 116, 1992, pages 705 - 708
ISMAIL, M. M. ET AL., CHEM PAPERS, vol. 58, no. 2, 2004, pages 117 - 125
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 141: 366111
KAIGORODOVES, E. A. ET AL., CHEM. HETER. COMPD., vol. 33, no. 6, 1997, pages 752 - 753
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 128: 127976
See also references of EP 2420500A4
Attorney, Agent or Firm:
SAEKI, NORIO (JP)
Norio Saeki (JP)
Norio Saeki (JP)
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