Title:
PYRIDOLACTAM DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/030478
Kind Code:
A1
Abstract:
The present invention relates to a pyridolactam derivative, a preparation method therefor, and a medical use of a pharmaceutical composition comprising the derivative. Specifically, the present invention relates to a substituted pyridolactam derivative represented by general formula (I), a preparation method therefor and a pharmaceutical salt thereof, and a use thereof as a therapeutic agent, in particular as an HPK1 inhibitor, wherein the definition of each substituent in general formula (I) is the same as the definition in the description.
Inventors:
QIU HAIBO (CN)
SHEN DONGGUO (CN)
CHEN A HUAN (CN)
NIE KAIYU (CN)
ZHAO WEIFENG (CN)
MAO WENTAO (CN)
CHEN YOUXI (CN)
ZHANG HENG (CN)
YE CHENG (CN)
QIAN WENJIAN (CN)
CHEN LEI (CN)
SHEN DONGGUO (CN)
CHEN A HUAN (CN)
NIE KAIYU (CN)
ZHAO WEIFENG (CN)
MAO WENTAO (CN)
CHEN YOUXI (CN)
ZHANG HENG (CN)
YE CHENG (CN)
QIAN WENJIAN (CN)
CHEN LEI (CN)
Application Number:
PCT/CN2022/116670
Publication Date:
March 09, 2023
Filing Date:
September 02, 2022
Export Citation:
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
International Classes:
C07D471/04; A61K31/4196; A61K31/437; A61K31/444; A61P35/00
Domestic Patent References:
| WO2020100027A1 | 2020-05-22 | |||
| WO2019015559A1 | 2019-01-24 | |||
| WO2009014637A2 | 2009-01-29 |
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW CO., LTD. (CN)
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