Title:
PYRIDONE DERIVATIVE AND MEDICINE CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2013/085017
Kind Code:
A1
Abstract:
General formula (I):
The present invention pertains to: a pyridone derivate or a salt thereof represented by general formula (I); or a medicine containing the pyridone derivative or salt thereof as an active ingredient. [In the formula, ring A, R1, R2, R3 and R4 are specific groups.]
Inventors:
KAMEI NORIYUKI (JP)
SUMIKAWA YOSHITAKE (JP)
KAMIMURA DAIGO (JP)
TODO SHINGO (JP)
YAMADA TAKUYA (JP)
TOKUOKA SHOTA (JP)
SUMIKAWA YOSHITAKE (JP)
KAMIMURA DAIGO (JP)
TODO SHINGO (JP)
YAMADA TAKUYA (JP)
TOKUOKA SHOTA (JP)
Application Number:
PCT/JP2012/081736
Publication Date:
June 13, 2013
Filing Date:
December 07, 2012
Export Citation:
Assignee:
KAKEN PHARMA CO LTD (JP)
International Classes:
C07D401/06; A61K31/4439; A61K31/444; A61P1/02; A61P1/04; A61P3/10; A61P7/06; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P27/06; A61P29/00; A61P31/04; A61P35/00; A61P37/00; A61P37/06; A61P37/08; A61P43/00; C07D401/14; C07D405/14; C07D409/14; C07K7/06
Domestic Patent References:
WO2003022801A1 | 2003-03-20 | |||
WO2010054278A2 | 2010-05-14 | |||
WO2010036640A2 | 2010-04-01 | |||
WO2010036638A2 | 2010-04-01 | |||
WO2007084455A1 | 2007-07-26 | |||
WO2007084415A2 | 2007-07-26 | |||
WO2006019768A1 | 2006-02-23 | |||
WO2005085232A1 | 2005-09-15 | |||
WO2004024721A1 | 2004-03-25 | |||
WO2004033632A2 | 2004-04-22 | |||
WO2004108086A2 | 2004-12-16 | |||
WO2003022801A1 | 2003-03-20 | |||
WO2010054278A2 | 2010-05-14 | |||
WO2010036640A2 | 2010-04-01 | |||
WO2007084455A1 | 2007-07-26 | |||
WO2007084415A2 | 2007-07-26 | |||
WO2006019768A1 | 2006-02-23 | |||
WO2005085232A1 | 2005-09-15 | |||
WO2004024721A1 | 2004-03-25 | |||
WO2004033632A2 | 2004-04-22 | |||
WO2004108086A2 | 2004-12-16 |
Other References:
WENSHENG YU ET AL.: "Discovery and SAR of hydantoin TACE inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, 2010, pages 1877 - 1880, XP026932848
WENSHENG YU ET AL.: "Biaryl substituted hydantoin compounds as TACE inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, 2010, pages 5286 - 5289, XP027207976
VINAY M. GIRIJAVALLABHAN ET AL.: "Novel TNF-a converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, 2010, pages 7283 - 7287, XP027501424
"Human Cytokines: Their Role in Disease and Therapy", 1995, BLACKWELL SCI
NELSON, F. C. ET AL., EXP. OPIN. INVEST. DRUGS, vol. 8, 1999, pages 383 - 392
MURUMKAR, P. R., EXP. OPIN. THER. PATENTS, vol. 20, 2010, pages 31 - 57
MOHLER, K. M. ET AL., NATURE, vol. 370, 1994, pages 218 - 220
DASGUPTA, S. ET AL., BIOORG. MED. CHEM., vol. 17, 2009, pages 444 - 459
NAKAJIMA, M., THE BONE, vol. 15, 2001, pages 161 - 166
HOLMBECK, K. ET AL., CELL, vol. 99, 1999, pages 81 - 92
YU, W. ET AL., BIOORG. MED. CHEM. LETT., vol. 20, 2010, pages 1877 - 1880
YU, W. ET AL., BIOORG. MED. CHEM. LETT., vol. 20, 2010, pages 5286 - 5289
MOSS, M. L. ET AL., NATURE, vol. 385, 1997, pages 733 - 736
D. MARK BICKETT ET AL., ANAL. BIOCHEM., vol. 212, 1993, pages 58 - 64
H. NAGASE ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 20952 - 20957
See also references of EP 2789607A4
WENSHENG YU ET AL.: "Biaryl substituted hydantoin compounds as TACE inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, 2010, pages 5286 - 5289, XP027207976
VINAY M. GIRIJAVALLABHAN ET AL.: "Novel TNF-a converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, 2010, pages 7283 - 7287, XP027501424
"Human Cytokines: Their Role in Disease and Therapy", 1995, BLACKWELL SCI
NELSON, F. C. ET AL., EXP. OPIN. INVEST. DRUGS, vol. 8, 1999, pages 383 - 392
MURUMKAR, P. R., EXP. OPIN. THER. PATENTS, vol. 20, 2010, pages 31 - 57
MOHLER, K. M. ET AL., NATURE, vol. 370, 1994, pages 218 - 220
DASGUPTA, S. ET AL., BIOORG. MED. CHEM., vol. 17, 2009, pages 444 - 459
NAKAJIMA, M., THE BONE, vol. 15, 2001, pages 161 - 166
HOLMBECK, K. ET AL., CELL, vol. 99, 1999, pages 81 - 92
YU, W. ET AL., BIOORG. MED. CHEM. LETT., vol. 20, 2010, pages 1877 - 1880
YU, W. ET AL., BIOORG. MED. CHEM. LETT., vol. 20, 2010, pages 5286 - 5289
MOSS, M. L. ET AL., NATURE, vol. 385, 1997, pages 733 - 736
D. MARK BICKETT ET AL., ANAL. BIOCHEM., vol. 212, 1993, pages 58 - 64
H. NAGASE ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 20952 - 20957
See also references of EP 2789607A4
Attorney, Agent or Firm:
ASAMURA PATENT OFFICE, p. c. (JP)
Patent business corporation Asamura patent firm (JP)
Patent business corporation Asamura patent firm (JP)
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