Title:
PYRIDONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2020/162471
Kind Code:
A1
Abstract:
Provided is a novel compound capable of inhibiting a bond between a BET protein and acetylated lysine. The present invention relates to, for example, the compound represented by general formula (1) or a salt thereof, and a pharmaceutical composition containing said compound as an active ingredient. (In the formula, R1 is H, a lower alkyl, or the like. R2 is H or a lower alkyl. R3 is an aryl that may be substituted, or the like. R4 is H, a lower alkyl that may be substituted, a heterocyclic group that may be substituted, or the like. X1, X2, and X3 are C or N. A double line of a solid line and a dotted line represents a single bond or a double bond.) The compound according to the present invention is effective in treating cancer, non-cancerous proliferative diseases, and the like.
Inventors:
HAGA YUJI (JP)
SUDA NAOKI (JP)
MUKOYAMA YOHEI (JP)
ITO HIROAKI (JP)
HORAI YUHEI (JP)
SUDA NAOKI (JP)
MUKOYAMA YOHEI (JP)
ITO HIROAKI (JP)
HORAI YUHEI (JP)
Application Number:
PCT/JP2020/004209
Publication Date:
August 13, 2020
Filing Date:
February 05, 2020
Export Citation:
Assignee:
MARUHO KK (JP)
International Classes:
A61K31/4439; A61P29/00; A61K31/444; A61K31/4545; A61K31/4709; A61K31/501; A61K31/506; A61K31/5377; A61P31/12; A61P35/00; A61P43/00; C07D401/04; C07D405/14; C07D409/14; C07D413/14; C07D417/04; C07D471/04
Domestic Patent References:
| WO2017066876A1 | 2017-04-27 |
Foreign References:
| JP2018522925A | 2018-08-16 | |||
| JP2018511626A | 2018-04-26 | |||
| JP2016530259A | 2016-09-29 | |||
| JP2018507903A | 2018-03-22 | |||
| JP2016520117A | 2016-07-11 |
Other References:
WELLAWAY, CHRISTOPHER R. ET AL.: "Discovery of a bromodomain and extraterminal inhibitor with a low predicted human dose through synergistic use of encoded library technoloty and fragment screening", JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, 6 January 2020 (2020-01-06), pages 714 - 746, XP055729101
HAY, DUNCAN A.: "Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136, 19 June 2014 (2014-06-19), pages 9308 - 9319, XP055559339, DOI: 10.1021/ja412434f
HAY, DUNCAN A.: "Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136, 19 June 2014 (2014-06-19), pages 9308 - 9319, XP055559339, DOI: 10.1021/ja412434f
Attorney, Agent or Firm:
SHIMIZU Naoto (JP)
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