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Title:
PYRIDONE-SUBSTITUTED-DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2009/054332
Kind Code:
A1
Abstract:
Disclosed are: a compound represented by the formula (I-0); and others. (I-0) wherein R1 represents a C1-C6 alkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group or a C3-C6 cycloalkyl group; R2, R3, R4 and R5 independently represent a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6-alkyl group, a C1-C6 alkoxy group or a halo-C1-C6-alkoxy group; R6 represents a hydrogen atom or a C1-C6 alkyl group; R7a represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6-alkyl group, a C1-C6 alkoxy group, a hydroxy-C1-C6-alkyl group, -Q2-N(R1c)R1d or a nitrogenated heterocyclic group; R8a represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6-alkyl group, a C1-C6 alkoxy group or a hydroxy-C1-C6-alkyl group; or R7a and R8a may together form a C2-C6 alkylene group, or R7a, R8a and a ring atom to which R7a and R8a are attached may together form a spiro ring or a bicyclo ring; and X and Y independently represent a methine group or a nitrogen atom. The compound has an excellent inhibitory activity on Wee1 kinase and therefore exhibits an inhibitory activity on the proliferation of a cell and an additive/synergistic effect with a different anti-cancer agent. Therefore, the compound is useful in the medical field.

Inventors:
FRUYAMA HIDETOMO (JP)
KAWAMURA MIKAKO (JP)
SAKAMOTO TOSHIHIRO (JP)
YAMAMOTO FUYUKI (JP)
YOSHIZUMI TAKASHI (JP)
Application Number:
PCT/JP2008/068932
Publication Date:
April 30, 2009
Filing Date:
October 20, 2008
Export Citation:
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Assignee:
BANYU PHARMA CO LTD (JP)
FRUYAMA HIDETOMO (JP)
KAWAMURA MIKAKO (JP)
SAKAMOTO TOSHIHIRO (JP)
YAMAMOTO FUYUKI (JP)
YOSHIZUMI TAKASHI (JP)
International Classes:
C07D487/04; A61K31/519; A61K39/395; A61K45/00; A61P35/00; A61P35/02; A61P43/00; C07D519/00
Domestic Patent References:
WO2007126128A12007-11-08
WO2006091737A12006-08-31
WO2006074985A12006-07-20
WO2003091255A12003-11-06
WO2004056786A22004-07-08
WO2005021532A12005-03-10
WO2006091737A12006-08-31
WO2007067506A22007-06-14
WO2004104007A12004-12-02
WO1996040210A11996-12-19
WO1994010202A11994-05-11
Foreign References:
JP2007503450A2007-02-22
JP2006515298A2006-05-25
US20050250836A12005-11-10
US5770599A1998-06-23
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Other References:
CELL PROLIFERATION, vol. 33, pages 261 - 274
THE EMBO JOURNAL, vol. 12, pages 75 - 85
CANCER BIOLOGY & THERAPY, vol. 3, pages 305 - 313
CANCER RESEARCH, vol. 61, pages 8211 - 8217
BIOORG & MED. CHEM. LETT., vol. 15, pages 1931 - 1935
JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, pages 2371 - 2387
NITTA ET AL., GAN TO KAGAKU RYOHO, vol. 14, 1987, pages 850 - 857
See also references of EP 2213673A4
Attorney, Agent or Firm:
BANYU PHARMACEUTICAL CO., LTD. (1-13-12 Kudankita,Chiyoda-k, Tokyo 67, JP)
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