Title:
PYRIDYLACRYLAMIDE DERIVATIVES AND NEPHRITIS REMEDIES AND TGF-$g(b) INHIBITORS CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/1999/005109
Kind Code:
A1
Abstract:
Compounds represented by general formula (I), and nephritis remedies and TGF-$g(b) inhibitors containing the same, wherein Ar?1¿ is (substituted) pyridyl; Ar?2¿ is (substituted) phenyl; R?1¿ is H, alkyl or aryl; R?2¿ is H, alkyl, cyano or alkoxycarbonyl; R?3¿ is H or (substituted) alkyl; X is O or S; A and B are each H, OH, alkoxy or alkylthio, or alternatively they together form oxo, thioxo, =N-Y (wherein Y is dialkylamino, OH, aralkyloxy or alkoxy) or -Z?1¿-M-Z?2¿- (wherein Z?1¿ and Z?2¿ are each O, S or optionally alkyl-substituted imino; and M is alkylene or phenylene), or B may be 1-alkylimidazol-2-yl with A being OH; and n is an integer of 1 to 3.
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Inventors:
HASEGAWA YOSHIHIRO (JP)
SHINDOU SHOUICHIROU (JP)
HATTORI TOMOHISA (JP)
YAMAZAKI YOUSUKE (JP)
OBATA TATSUHIRO (JP)
HORIUCHI FUMIKO (JP)
HAYAKAWA HIROYUKI (JP)
KUMAZAWA HIROAKI (JP)
SHINDOU SHOUICHIROU (JP)
HATTORI TOMOHISA (JP)
YAMAZAKI YOUSUKE (JP)
OBATA TATSUHIRO (JP)
HORIUCHI FUMIKO (JP)
HAYAKAWA HIROYUKI (JP)
KUMAZAWA HIROAKI (JP)
Application Number:
PCT/JP1998/003312
Publication Date:
February 04, 1999
Filing Date:
July 24, 1998
Export Citation:
Assignee:
TSUMURA & CO (JP)
HASEGAWA YOSHIHIRO (JP)
SHINDO SHOUICHIROU (JP)
HATTORI TOMOHISA (JP)
YAMAZAKI YOUSUKE (JP)
OBATA TATSUHIRO (JP)
HORIUCHI FUMIKO (JP)
HAYAKAWA HIROYUKI (JP)
KUMAZAWA HIROAKI (JP)
HASEGAWA YOSHIHIRO (JP)
SHINDO SHOUICHIROU (JP)
HATTORI TOMOHISA (JP)
YAMAZAKI YOUSUKE (JP)
OBATA TATSUHIRO (JP)
HORIUCHI FUMIKO (JP)
HAYAKAWA HIROYUKI (JP)
KUMAZAWA HIROAKI (JP)
International Classes:
C07D213/56; (IPC1-7): C07D213/57; A61K31/44; A61K31/535; C07D213/56; C07D213/59; C07D213/61; C07D213/66; C07D213/80; C07D401/12
Domestic Patent References:
| WO1995024896A2 | 1995-09-21 | |||
| WO1994026303A1 | 1994-11-24 | |||
| WO1995013264A1 | 1995-05-18 |
Foreign References:
| JPH08333249A | 1996-12-17 | |||
| JPH0892191A | 1996-04-09 |
Other References:
BORDER W A, NOBLE N A, KETTELER M: "TGF-BETA: A CYTOKINE MEDIATOR OF GLOMERULOSCLEROSIS AND A TARGET FOR THERAPEUTIC INTERVENTION", KIDNEY INTERNATIONAL, NATURE PUBLISHING GROUP, LONDON, GB, vol. 47, no. SUPPL. 49, 1 January 1995 (1995-01-01), LONDON, GB, pages S - 59, XP002917857, ISSN: 0085-2538
KOBAYASHI S, YAMAMOTO T: "THE MOLECULAR BIOLOGIC STUDY OF THE EXPRESSION OF THROMBOSPONDIN INVASCULAR SMOOTH MUSCLE CELLS AND MESANGIAL CELLS", JOURNAL OF DIABETES AND ITS COMPLICATIONS, ELSEVIER SCIENCE, NEW YORK, NY, US, vol. 05, no. 02/03, 1 January 1991 (1991-01-01), US, pages 121 - 123, XP002917858, ISSN: 1056-8727
See also references of EP 1000935A4
KOBAYASHI S, YAMAMOTO T: "THE MOLECULAR BIOLOGIC STUDY OF THE EXPRESSION OF THROMBOSPONDIN INVASCULAR SMOOTH MUSCLE CELLS AND MESANGIAL CELLS", JOURNAL OF DIABETES AND ITS COMPLICATIONS, ELSEVIER SCIENCE, NEW YORK, NY, US, vol. 05, no. 02/03, 1 January 1991 (1991-01-01), US, pages 121 - 123, XP002917858, ISSN: 1056-8727
See also references of EP 1000935A4
Attorney, Agent or Firm:
Hiraki, Yusuke (Toranomon 1-chome Minato-ku Tokyo, JP)
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