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Title:
PYRIMIDINE-4(3H)-KETONE HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE AND PHARMACOLOGY
Document Type and Number:
WIPO Patent Application WO/2021/143701
Kind Code:
A1
Abstract:
The present invention relates to a pyrimidine-4(3H)-ketone heterocyclic compound suitable for inhibiting or regulating SHP2, a preparation method therefor and a use thereof in medicine and pharmacology. In particular, the present invention relates to the compound shown in a general formula (I) and a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the compound or the pharmaceutically acceptable salt thereof, a method for treating and/or preventing SHP2-mediated related diseases, in particular cancer, by using the compound or the pharmaceutically acceptable salt thereof and a preparation method for the compound or the pharmaceutically acceptable salt thereof. The present invention further relates to the use of the compound or the pharmaceutically acceptable salt thereof or the pharmaceutical composition containing the compound or the pharmaceutically acceptable salt thereof in the preparation of a medicine for treating and/or preventing the SHP2-mediated related diseases. Each substituent of the general formula (I) has the same definition as in the description.

Inventors:
CHEN XIANGYANG (CN)
GAO YINGXIANG (CN)
Application Number:
PCT/CN2021/071375
Publication Date:
July 22, 2021
Filing Date:
January 13, 2021
Export Citation:
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Assignee:
BEIJING INNOCARE PHARMA TECH CO LTD (CN)
International Classes:
C07D471/04; A61K31/506; A61P35/00; C07D401/14; C07D471/10
Domestic Patent References:
WO2018130928A12018-07-19
WO2015107495A12015-07-23
WO2016203405A12016-12-22
WO2018057884A12018-03-29
WO2018013597A12018-01-18
WO2017211303A12017-12-14
Foreign References:
CN107787323A2018-03-09
CN109311848A2019-02-05
Other References:
RUESS DA ET AL., NAT. MED., vol. 24, 2018, pages 954 - 960
LI J ET AL., CANCER RES, vol. 75, 2015, pages 508 - 518
CHEN Y ET AL., NATURE, vol. 535, 2016, pages 148 - 52
See also references of EP 4092024A4
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