Title:
PYRIMIDINE COMPOUND AS WEE-1 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2022/174796
Kind Code:
A1
Abstract:
Disclosed are a pyrimidine compound represented by formula (1) as a Wee-1 inhibitor, a preparation method therefor, and an application of the compound represented by formula (1) and various isomers, crystal forms, pharmaceutically acceptable salts, hydrates, or solvates thereof as Wee-1 inhibitors in preparation of antitumor drugs.
Inventors:
XIE YULI (CN)
WU YINGMING (CN)
FAN HOUXING (CN)
QIAN LIHUI (CN)
WU YINGMING (CN)
FAN HOUXING (CN)
QIAN LIHUI (CN)
Application Number:
PCT/CN2022/076671
Publication Date:
August 25, 2022
Filing Date:
February 17, 2022
Export Citation:
Assignee:
WIGEN BIOMEDICINE TECH SHANGHAI CO LTD (CN)
International Classes:
C07D401/14; A61K31/444; A61K31/506; A61P35/00; C07D413/14; C07D417/14
Domestic Patent References:
WO2020192581A1 | 2020-10-01 | |||
WO2018011569A1 | 2018-01-18 | |||
WO2006099974A1 | 2006-09-28 |
Foreign References:
KR20200016567A | 2020-02-17 | |||
CN110467615A | 2019-11-19 | |||
CN109627263A | 2019-04-16 | |||
CN202110192274A | 2021-02-19 | |||
CN202110815600A | 2021-07-19 | |||
CN202210129460A | 2022-02-11 |
Other References:
CURR CLIN PHARMACOL, vol. 5, no. 3, 2010, pages 186 - 191
J CELL BIOL, vol. 194, no. 4, 2011, pages 567 - 579
PLOS ONE, vol. 4, no. 4, 2009, pages 5120
HEPATOLOGY, vol. 37, no. 3, 2003, pages 534 - 543
MOL CANCER, vol. 13, 2014, pages 72
CANCER BIOL THER, vol. 9, no. 7, 2010, pages 514 - 522
MOL CANCER THER, vol. 8, no. 11, 2009, pages 2992 - 3000
CAREYSUNDBERG: "ADVANCED ORGANIC CHEMISTRY", 2001, PLENUM 2000
GREENWUTS: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS", 1999, WILEY
J CELL BIOL, vol. 194, no. 4, 2011, pages 567 - 579
PLOS ONE, vol. 4, no. 4, 2009, pages 5120
HEPATOLOGY, vol. 37, no. 3, 2003, pages 534 - 543
MOL CANCER, vol. 13, 2014, pages 72
CANCER BIOL THER, vol. 9, no. 7, 2010, pages 514 - 522
MOL CANCER THER, vol. 8, no. 11, 2009, pages 2992 - 3000
CAREYSUNDBERG: "ADVANCED ORGANIC CHEMISTRY", 2001, PLENUM 2000
GREENWUTS: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS", 1999, WILEY
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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