Title:
PYRIMIDINE COMPOUND, CHLORIDE SALT THEREOF, AND MANUFACTURING AND APPLICATION OF SAME
Document Type and Number:
WIPO Patent Application WO/2017/219688
Kind Code:
A1
Abstract:
The present invention relates to a pyrimidine compound, a chloride salt thereof, and a manufacturing and application of same. The chloride salt of the pyrimidine compound is represented by formula (II). The chloride salt has higher solubility, good stability, higher bioavailability, and very low hygroscopicity, and has excellent inhibition against a PIM kinase.
Inventors:
CAI WEIHUI (CN)
ZHANG YUANWEI (CN)
JIN FANG (CN)
ZHANG YUANWEI (CN)
JIN FANG (CN)
Application Number:
PCT/CN2017/073654
Publication Date:
December 28, 2017
Filing Date:
February 15, 2017
Export Citation:
Assignee:
SHANGHAI FRONT HEALTH PHARMACEUTICAL TECH CO LTD (CN)
SHENZHEN HAIBIN PHARMACEUTICAL (CN)
SHENZHEN HAIBIN PHARMACEUTICAL (CN)
International Classes:
C07D417/14; A61K31/506; A61P9/10; A61P35/00; A61P37/06; A61P37/08
Domestic Patent References:
| WO2014033631A1 | 2014-03-06 |
Foreign References:
| CN102924446A | 2013-02-13 | |||
| CN102203079A | 2011-09-28 | |||
| CN201210271738A | 2012-08-01 |
Other References:
IMMUNOLOGY, vol. 116, 2005, pages 82 - 88
"Guiding Principles of Active Pharmaceutical Ingredient and Pharmaceutical Formulation Stability Test", APPENDIX XIX C, SECOND PART, CHINESE PHARMACOPEIA, 2010
See also references of EP 3476843A4
"Guiding Principles of Active Pharmaceutical Ingredient and Pharmaceutical Formulation Stability Test", APPENDIX XIX C, SECOND PART, CHINESE PHARMACOPEIA, 2010
See also references of EP 3476843A4
Attorney, Agent or Firm:
LEADING INTELLECTUAL PROPERTY FIRM (CN)
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