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Title:
PYRIMIDINE-CONTAINING DIHYDROPYRAZOLONE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/041066
Kind Code:
A1
Abstract:
Provided are a pyrimidine-containing dihydropyrazolone derivative, a prodrug thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and a preparation method therefor and an application thereof. The compound can inhibit Wee1 and has better selectivity to Plk1, and can treat cancer.

Inventors:
ZHOU GUOQIANG (CN)
WEI YI (CN)
YUAN HONGBIN (CN)
LIU KUN CHIN (CN)
Application Number:
PCT/CN2022/119440
Publication Date:
March 23, 2023
Filing Date:
September 16, 2022
Export Citation:
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Assignee:
ACERAND THERAPEUTICS HONG KONG LTD (CN)
International Classes:
C07D519/00; A61K31/519; A61K31/5383; A61K31/5386; A61P35/00; C07D471/22; C07D487/02; C07D487/22
Domestic Patent References:
WO2020083404A12020-04-30
WO2019085933A12019-05-09
WO2021168074A12021-08-26
WO2019134539A12019-07-11
WO2019074979A12019-04-18
Foreign References:
CN113387962A2021-09-14
CN108623615A2018-10-09
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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