Title:
PYRIMIDINE DERIVATIVE PIM KINASE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN MEDICINE PREPARATION
Document Type and Number:
WIPO Patent Application WO/2017/045612
Kind Code:
A1
Abstract:
A PIM kinase inhibitor, a preparation method therefor, and application thereof. A structural formula thereof is a compound as shown in a following general formula I. Also provided are a stereoisomer, a tautomer, and pharmaceutical salt of the compound in the general formula I. The compound of the general formula I has an obvious inhibiting function on the activity of kinase, can be used as the PIM kinase inhibitor, can be used for preparing medicine for treating or preventing cancer, reversing the drug resistance of anticancer medicine and other medicine, treating or preventing diseases of inflammatory bowel disease, autoimmune diseases and the like, and has a great clinical application value.
Inventors:
GE YU (CN)
Application Number:
PCT/CN2016/099040
Publication Date:
March 23, 2017
Filing Date:
September 14, 2016
Export Citation:
Assignee:
JIKAI BIOSCIENCES，INC (CN)
International Classes:
C07D401/14; A61K31/506; A61P9/10; A61P35/00; C07D401/12; C07D405/14
Foreign References:
| CN102924446A | 2013-02-13 | |||
| CN102203079A | 2011-09-28 | |||
| CN101679266A | 2010-03-24 |
Other References:
ZHENG, XIAOZHOU ET AL.: "xiao3fenlzi3 PIM jilmei2 yi4zhi4ji4 de4 yan3jiul jin4zhan3", CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 23, no. 6, 31 December 2013 (2013-12-31), pages 499 - 505
Attorney, Agent or Firm:
SUNSHINE INTELLECTUAL PROPERTY INTERNATIONAL CO., LTD (CN)
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