Title:
PYRIMIDINE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/076355
Kind Code:
A1
Abstract:
The present invention provides a pyrimidine derivative and a use thereof. The pyrimidine derivative is the compound shown in formula I or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein, R1, R2, R3, R4 and R5 are, for example, as defined in the specification. The compound can act as an ALK inhibitor, and is for preparing an anti-tumor medicament for suppressing an anaplastic lymphoma kinase.
Inventors:
WANG XUEHAI (CN)
XU YONG (CN)
SHENG XIJUN (CN)
ZHANG XIAOLIN (CN)
XIA HANGUI (CN)
YANG ZHONGWEN (CN)
YUE YANG (CN)
HUANG LU (CN)
XIAO QIANG (CN)
XU YONG (CN)
SHENG XIJUN (CN)
ZHANG XIAOLIN (CN)
XIA HANGUI (CN)
YANG ZHONGWEN (CN)
YUE YANG (CN)
HUANG LU (CN)
XIAO QIANG (CN)
Application Number:
PCT/CN2016/104723
Publication Date:
May 11, 2017
Filing Date:
November 04, 2016
Export Citation:
Assignee:
HUBEI BIOLOGICAL MEDICINE IND TECH INST CO LTD (CN)
HUMANWELL HEALTHCARE (GROUP) CO LTD (CN)
HUMANWELL HEALTHCARE (GROUP) CO LTD (CN)
International Classes:
C07D409/12; A61K31/506; A61K31/5377; A61P35/00; C07D239/48; C07D401/12; C07D401/14; C07D409/14; C07D413/14
Domestic Patent References:
| WO2015130014A1 | 2015-09-03 |
Foreign References:
| CN104672214A | 2015-06-03 | |||
| CN101616895A | 2009-12-30 | |||
| CN104860922A | 2015-08-26 |
Other References:
See also references of EP 3372594A4
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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