PYRIMIDINE DERIVATIVE - DAINIPPON SUMITOMO PHARMA CO

Title:

PYRIMIDINE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2014/054634

Kind Code:

A1

Abstract:

Provided is a therapeutic agent for diseases associated with a cholinergic property of the central nervous system (CNS) and/or the peripheral nervous system (PNS), diseases associated with the contraction of smooth muscle, incretion diseases, diseases associated with neuronal degeneration and the like, said therapeutic agent comprising a compound represented by formula (I) [wherein X-Y-Z represents NR6-N=C or the like; A represents CR1D or the like; B1 represents a nitrogen atom or the like; B2 represents a single bond or the like; R1A to R1D may be the same as or different from one another and independently represent a hydrogen atom or the like; R2A to R2E may be the same as or different from one another and independently represent a hydrogen atom or the like; and R3, R4 and R5 may be the same as or different from one another and independently represent a hydrogen atom or the like] or a pharmaceutically acceptable salt thereof and having a potent activity of regulating an α7 nicotinic acetylcholine receptor (an α7 nAChR).

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Inventors:

NAKAI YOKO (JP)
USUI SHINYA (JP)

Application Number:

PCT/JP2013/076693

Publication Date:

April 10, 2014

Filing Date:

October 01, 2013

Export Citation:

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Assignee:

DAINIPPON SUMITOMO PHARMA CO (JP)

International Classes:

C07D401/14; A61K31/506; A61P5/00; A61P21/00; A61P25/00; A61P25/02; A61P25/18; A61P25/28; A61P25/36; A61P29/00; A61P43/00; C07D403/12; C07D413/14; C07D471/04; C12N15/00

Domestic Patent References:

WO2011045353A1	2011-04-21
WO2009124882A1	2009-10-15
WO2011105572A1	2011-09-01
WO2012176763A1	2012-12-27
WO2012133509A1	2012-10-04

Foreign References:

JPH03188077A

1991-08-16

Other References:

ZAVERI, NURULAIN ET AL.: "Novel a3p4 Nicotinic Acetylcholine Receptor-Selective Ligands. Discovery, Structure-Activity Studies, and Pharmacological Evaluation", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 22, 2010, pages 8187 - 8191

Attorney, Agent or Firm:

SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)

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