Title:
PYRIMIDINE-FUSED CYCLIC COMPOUND AND USE THEREOF IN PREPARATION OF DRUG FOR TREATING PAIN AND SPINAL CORD INJURY
Document Type and Number:
WIPO Patent Application WO/2022/194261
Kind Code:
A1
Abstract:
A compound as represented by formula (I), a stereoisomer and tautomer thereof or a pharmaceutically acceptable salt thereof, and the use thereof in the preparation of a drug for treating pain and a spinal cord injury.
Inventors:
LI JIN (CN)
YANG MINMIN (CN)
YANG MINMIN (CN)
Application Number:
PCT/CN2022/081573
Publication Date:
September 22, 2022
Filing Date:
March 18, 2022
Export Citation:
Assignee:
PHARMABLOCK SCIENCES NANJING INC (CN)
International Classes:
C07D255/04; A61K31/495; A61P29/00; C07D401/12; C07D403/12; C07D405/12
Domestic Patent References:
| WO2017059191A1 | 2017-04-06 | |||
| WO2009086303A2 | 2009-07-09 |
Foreign References:
| EP0276825A1 | 1988-08-03 | |||
| US3186991A | 1965-06-01 | |||
| CN102643269A | 2012-08-22 |
Other References:
JIAN YANLIN, FORBES HE EUN, HULPIA FABIAN, RISSEEUW MARTIJN D. P., CALJON GUY, MUNIER-LEHMANN HÉLÈNE, BOSHOFF HELENA I. M., VAN CA: "2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F 420 )-Dependent Nitroreductase (Ddn)", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 1, 14 January 2021 (2021-01-14), US , pages 440 - 457, XP055968345, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c01374
SÁNCHEZ, A. I. ET AL.,: "Synthesis and evaluation of quinazoline derivatives as phosphodiesterase 7 inhibitors,", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, 24 February 2013 (2013-02-24), XP028596329, DOI: 10.1016/j.bmc.2013.01.067
TIMOTHY P. SPICER, JIANWEN JIANG, ALEXANDER B. TAYLOR, JUN YONG CHOI, P. JOHN HART, WILLIAM R. ROUSH, GREGG B. FIELDS, PETER S. HO: "Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation in Vitro", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 57, no. 22, 26 November 2014 (2014-11-26), US , pages 9598 - 9611, XP055492830, ISSN: 0022-2623, DOI: 10.1021/jm501284e
FAKHARI ALI, HASHEMINASAB KOBRA, AHMAR HAMID, ALIZADEH ABDOLALI: "An Efficient Synthesis of Thio- and Thiazoloquinazolinones by the Electrochemical Oxidation of Catechols in the Presence of 2-Mercapto-4(3 H )-quinazolinone", SYNTHESIS, GEORG THIEME VERLAG, STUTTGART, DE., vol. 2008, no. 24, 1 December 2008 (2008-12-01), STUTTGART, DE. , pages 3963 - 3966, XP055968344, ISSN: 0039-7881, DOI: 10.1055/s-0028-1083258
SÁNCHEZ, A. I. ET AL.,: "Synthesis and evaluation of quinazoline derivatives as phosphodiesterase 7 inhibitors,", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, 24 February 2013 (2013-02-24), XP028596329, DOI: 10.1016/j.bmc.2013.01.067
TIMOTHY P. SPICER, JIANWEN JIANG, ALEXANDER B. TAYLOR, JUN YONG CHOI, P. JOHN HART, WILLIAM R. ROUSH, GREGG B. FIELDS, PETER S. HO: "Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation in Vitro", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 57, no. 22, 26 November 2014 (2014-11-26), US , pages 9598 - 9611, XP055492830, ISSN: 0022-2623, DOI: 10.1021/jm501284e
FAKHARI ALI, HASHEMINASAB KOBRA, AHMAR HAMID, ALIZADEH ABDOLALI: "An Efficient Synthesis of Thio- and Thiazoloquinazolinones by the Electrochemical Oxidation of Catechols in the Presence of 2-Mercapto-4(3 H )-quinazolinone", SYNTHESIS, GEORG THIEME VERLAG, STUTTGART, DE., vol. 2008, no. 24, 1 December 2008 (2008-12-01), STUTTGART, DE. , pages 3963 - 3966, XP055968344, ISSN: 0039-7881, DOI: 10.1055/s-0028-1083258
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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