Title:
PYRIMIDINE TRICYCLIC ENONE DERIVATIVES FOR INHIBITION OF RORγ AND OTHER USES
Document Type and Number:
WIPO Patent Application WO/2018/111315
Kind Code:
A8
Abstract:
Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.
Inventors:
JIANG XIN (US)
BENDER CHRISTOPHER (US)
VISNICK MELEAN (US)
HOTEMA MARTHA (US)
SHELDON ZACHARY (US)
LEE CHITASE (US)
CAPRATHE BRADLEY (US)
BOLTON GARY (US)
KORNBERG BRIAN (US)
BENDER CHRISTOPHER (US)
VISNICK MELEAN (US)
HOTEMA MARTHA (US)
SHELDON ZACHARY (US)
LEE CHITASE (US)
CAPRATHE BRADLEY (US)
BOLTON GARY (US)
KORNBERG BRIAN (US)
Application Number:
PCT/US2017/000094
Publication Date:
July 11, 2019
Filing Date:
December 16, 2017
Export Citation:
Assignee:
REATA PHARMACEUTICALS INC (US)
International Classes:
C07D401/04; A61K31/517; A61P29/00; A61P35/00; A61P37/00; C07D221/04; C07D401/12; C07D403/04; C07D413/04
Attorney, Agent or Firm:
LONG, S., Reid (US)
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