Title:
PYRIMIDINONE DERIVATIVE HAVING AUTOTAXIN-INHIBITORY ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2016/031987
Kind Code:
A1
Abstract:
A compound represented by any of formulas (Ia)-(Ic) or formula (II), or a pharmaceutically acceptable salt thereof. (In the formulas, R1, R2, R3, R4a, R4c, R5, R15, ring A, X1, and X2 are as defined in the specification.)
Inventors:
NAGANO TETSUO (JP)
OKABE TAKAYOSHI (JP)
KOJIMA HIROTATSU (JP)
KAWAGUCHI MITSUYASU (JP)
NUREKI OSAMU (JP)
ISHITANI RYUICHIRO (JP)
NISHIMASU HIROSHI (JP)
AOKI JUNKEN (JP)
TANAKA NOBUYUKI (JP)
KANDA YASUHIKO (JP)
KIOI YOSHIYUKI (JP)
TATENO YUSUKE (JP)
KIDA SHIRO (JP)
YAMANE JUNJI (JP)
WADA TOSHIHIRO (JP)
OKABE TAKAYOSHI (JP)
KOJIMA HIROTATSU (JP)
KAWAGUCHI MITSUYASU (JP)
NUREKI OSAMU (JP)
ISHITANI RYUICHIRO (JP)
NISHIMASU HIROSHI (JP)
AOKI JUNKEN (JP)
TANAKA NOBUYUKI (JP)
KANDA YASUHIKO (JP)
KIOI YOSHIYUKI (JP)
TATENO YUSUKE (JP)
KIDA SHIRO (JP)
YAMANE JUNJI (JP)
WADA TOSHIHIRO (JP)
Application Number:
PCT/JP2015/074522
Publication Date:
March 03, 2016
Filing Date:
August 28, 2015
Export Citation:
Assignee:
UNIV TOKYO (JP)
UNIV TOHOKU (JP)
SHIONOGI & CO (JP)
UNIV TOHOKU (JP)
SHIONOGI & CO (JP)
International Classes:
C07D239/47; A61K31/439; A61K31/513; A61K31/5377; A61K31/541; A61K31/551; A61P1/16; A61P3/10; A61P9/10; A61P11/00; A61P13/02; A61P13/12; A61P15/00; A61P17/00; A61P19/02; A61P21/00; A61P25/04; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/06; A61P43/00; C07D401/04; C07D401/06; C07D401/10; C07D401/12; C07D403/04; C07D403/06; C07D403/10; C07D403/12; C07D405/12; C07D409/12; C07D413/06; C07D413/10; C07D413/12; C07D417/12; C07D453/02; C07D491/107; C07D498/08
Domestic Patent References:
| WO1993001198A1 | 1993-01-21 | |||
| WO2000029387A1 | 2000-05-25 | |||
| WO2001068613A1 | 2001-09-20 | |||
| WO2007146761A2 | 2007-12-21 |
Foreign References:
| JPS62270563A | 1987-11-24 | |||
| JPS6144872A | 1986-03-04 |
Other References:
ANDREWS,M.D. ET AL.: "Design and synthesis of piperazinylpyrimidinones as novel selective 5- HT2C agonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 18, 2009, pages 5346 - 5350, XP026501157, ISSN: 0960-894X, DOI: doi:10.1016/j.bmcl.2009.07.133
SAITO,T. ET AL.: "Thermal or Lewis acid-promoted electrocyclization and hetero Diels-Alder cycloaddition of alpha,beta-unsaturated (conjugated) carbodiimides: a facile synthesis of nitrogen- containing heterocycles", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY, 1998, pages 3065 - 3080, XP055412157, ISSN: 0300-922X
NUGENT,R.A. ET AL.: "New antiinflammatory/ antiarthritic heterocyclic bisphosphonates", PHOSPHORUS, SULFUR AND SILICON AND THE RELATED ELEMENTS, vol. 109-110, 1996, pages 229 - 232, XP009500543, ISSN: 1042-6507
See also references of EP 3187492A4
SAITO,T. ET AL.: "Thermal or Lewis acid-promoted electrocyclization and hetero Diels-Alder cycloaddition of alpha,beta-unsaturated (conjugated) carbodiimides: a facile synthesis of nitrogen- containing heterocycles", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY, 1998, pages 3065 - 3080, XP055412157, ISSN: 0300-922X
NUGENT,R.A. ET AL.: "New antiinflammatory/ antiarthritic heterocyclic bisphosphonates", PHOSPHORUS, SULFUR AND SILICON AND THE RELATED ELEMENTS, vol. 109-110, 1996, pages 229 - 232, XP009500543, ISSN: 1042-6507
See also references of EP 3187492A4
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
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