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Title:
PYRIMIDINONE DERIVATIVE AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USE
Document Type and Number:
WIPO Patent Application WO/2022/233302
Kind Code:
A1
Abstract:
The present invention provides a compound as represented by general formula (I), a cis-trans isomer thereof, an enantiomer thereof, a diastereomer thereof, a racemate thereof, a solvate thereof, a hydrate thereof, or a pharmaceutically-acceptable salt thereof or a prodrug thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and a use of the compound as an Lp-PLA2 inhibitor, wherein R1, R2, Rx, Ry, Rz, Q, U, X, m, n, and A are defined in the description.

Inventors:
JIN YUN (CN)
PENG JUN (CN)
Application Number:
PCT/CN2022/090984
Publication Date:
November 10, 2022
Filing Date:
May 05, 2022
Export Citation:
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Assignee:
SHANGHAI SIMR BIOTECHNOLOGY CO LTD (CN)
SHANGHAI SIMRD BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07D498/22; A61K31/519; A61K31/529; A61K31/5383; A61P3/10; A61P7/10; A61P9/10; A61P13/12; A61P21/00; A61P25/00; A61P25/04; A61P25/16; A61P25/28; C07D471/14; C07D487/14; C07D487/18; C07D498/14
Domestic Patent References:
WO2016011930A12016-01-28
WO1996013484A11996-05-09
WO1996019451A11996-06-27
WO1997002242A11997-01-23
WO1997012963A21997-04-10
WO1997021675A11997-06-19
WO1997021676A11997-06-19
WO1997041098A11997-11-06
WO1997041099A11997-11-06
WO1999002442A11999-01-21
WO2000010980A12000-03-02
WO2000066566A12000-11-09
WO2000066567A12000-11-09
WO2000068208A12000-11-16
WO2001060805A12001-08-23
WO2002030904A12002-04-18
WO2002030911A12002-04-18
WO2003015786A12003-02-27
WO2003016287A22003-02-27
WO2003041712A12003-05-22
WO2003042179A12003-05-22
WO2003042206A12003-05-22
WO2003042218A12003-05-22
WO2003086400A12003-10-23
WO2003087088A22003-10-23
WO2008004886A12008-01-10
WO2008048866A22008-04-24
WO2005003118A12005-01-13
WO2006063811A22006-06-22
WO2006063813A22006-06-22
WO2008141176A12008-11-20
WO2013013503A12013-01-31
WO2013014185A12013-01-31
WO2014114248A12014-07-31
WO2014114694A12014-07-31
WO2016011930A12016-01-28
WO1999024420A11999-05-20
WO2008048867A22008-04-24
WO2012080497A22012-06-21
WO1997002037A11997-01-23
WO1998028310A11998-07-02
WO1998028311A11998-07-02
WO1998028312A11998-07-02
Foreign References:
CN113912622A2022-01-11
CN112778331A2021-05-11
CN112574221A2021-03-30
US20080103156A12008-05-01
US20080090851A12008-04-17
US20080090852A12008-04-17
JP2001088847A2001-04-03
US20080279846A12008-11-13
US20100239565A12010-09-23
US20080280829A12008-11-13
US20080279846A12008-11-13
CA2530816A12005-01-13
Other References:
ZALEWSKI A ET AL., ARTERIOSCLER. THROMB., vol. 25, no. 5, 2005, pages 923 - 31
WILENSKY ET AL., NATURE MEDICINE, vol. 10, 2008, pages 1015 - 1016
SERRUYS ET AL., CIRCULATION, vol. 118, 2008, pages 1172 - 1182
VAN OIJEN ET AL., ANNALS OF NEUROLOGY, vol. 59, 2006, pages 139
FITZPATRICK ET AL., ATHEROSCLEROSIS, vol. 235, 2014, pages 384 - 391
KASSNER ET AL., CURRENT ALZHEIMER RESEARCH, vol. 5, 2008, pages 358 - 366
DILDAR ET AL., ALZHEIMER DIS ASSOC DISORD, vol. 24, April 2010 (2010-04-01)
SINEM ET AL., CURRENT ALZHEIMER RESEARCH, vol. 7, 2010, pages 463 - 469
MAHER-EDWARDS ET AL., ALZHEIMER'S & DEMENTIA: TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS, vol. 1, 2015, pages 131 - 140
PERRY, ACTA NEUROPATHOL, vol. 120, 2010, pages 277 - 286
SHI ET AL., ATHEROSCLEROSIS, vol. 191, 2007, pages 54 - 62
WILENSKY ET AL., CURRENT OPINION IN LIPIDOLOGY, vol. 20, 2009, pages 415 - 420
SIDDIQUI ET AL., DIABETOLOGIA, vol. 61, 2018, pages 1344 - 1353
CANNING ET AL., P.N.A.S., vol. 113, 2016, pages 7213 - 7218
STAURENGHI ET AL., OPHTHALMOLOGY, vol. 122, 2015, pages 990 - 996
SERBAN ET AL., J. CELL. MOL. MED., vol. 6, 2002, pages 643 - 647
GARG ET AL., INDIAN J. MED. RES., vol. 141, 2015, pages 107 - 114
BUSCHINI ET AL., PROGRESS IN NEUROBIOLOGY, vol. 95, 2011, pages 14 - 25
TEZEL, PROGRESS IN BRAIN RESEARCH, vol. 173, ISSN: 0079-6123
OTUNCTEMUR ET AL., ANDROLOGIA, vol. 47, 2015, pages 706 - 710
VAINIO ET AL., ONCOTARGET, vol. 2, 2011, pages 1176 - 1190
BERGE ET AL., J. PHARM, SCI., vol. 66, 19 January 1977 (1977-01-19)
P L GOULD, INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 33, 1986, pages 201 - 217
BIGHLEY ET AL.: "Encyclopedia of Pharmaceutical Technology", vol. 13, 1996, MARCEL DEKKER INC, pages: 453 - 497
I.GREENEP.WUTS: "Protecting Groups in Chemical Synthesis", 1999, JOHN WILEY&SONS
"The Handbook of Pharmaceutical Excipients", AMERICAN PHARMACOLOGICAL ASSOCIATION AND DRUG PRESS
Attorney, Agent or Firm:
SUNSHINE INTELLECTUAL PROPERTY INTERNATIONAL CO., LTD. (CN)
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