PYRIMIDINYLISOXAZOL DERIVATIVE

Title:

PYRIMIDINYLISOXAZOL DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2006/070927

Kind Code:

A1

Abstract:

An isoxazol derivative, or its pharmacologically acceptable salt, having an excellent P38MAP kinase inhibiting potency, the pyrimidinylisoxazol derivative represented by the formula: wherein R¹ is a hydrogen atom, lower alkyl, amino, halogen atom, lower alkoxy, etc.; R² is a substituted or unsubstituted aryl, etc.; R³ is a hydrogen atom or lower alkyl; R⁴ is a substituted or unsubstituted phenyl, etc.; and Y is -CH₂-, -CO-, -CH(CH₃)-, -O-, -NH-, etc.

Inventors:

HASUMI KOICHI (JP)
OHTA SHUJI (JP)
SAITO TAKAHISA (JP)
SATO SHUICHIRO (JP)
KATO JUN-YA (JP)
SATO JUN (JP)
SUZUKI HIROYUKI (JP)
ASANO HAJIME (JP)
OKADA MAMI (JP)
MATSUMOTO YASUHIRO (JP)
SHIROTA KAZUHIKO (JP)

Application Number:

PCT/JP2005/024244

Publication Date:

July 06, 2006

Filing Date:

December 27, 2005

Export Citation:

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Assignee:

ASKA PHARM CO LTD (JP)
HASUMI KOICHI (JP)
OHTA SHUJI (JP)
SAITO TAKAHISA (JP)
SATO SHUICHIRO (JP)
KATO JUN-YA (JP)
SATO JUN (JP)
SUZUKI HIROYUKI (JP)
ASANO HAJIME (JP)
OKADA MAMI (JP)
MATSUMOTO YASUHIRO (JP)
SHIROTA KAZUHIKO (JP)

International Classes:

C07D413/04; A61K31/506; A61P1/00; A61P1/04; A61P1/16; A61P3/10; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P19/04; A61P19/06; A61P19/10; A61P25/00; A61P25/28; A61P27/00; A61P29/00; A61P31/04; A61P31/18; A61P35/00; A61P35/04; A61P37/02; A61P37/08; A61P43/00; C07D413/14

Domestic Patent References:

WO2002083668A1	2002-10-24
WO2004022555A1	2004-03-18
WO2003004492A1	2003-01-16

Foreign References:

JP2004536114A

2004-12-02

Other References: