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Title:
PYRROLE-BASED HMG-COA REDUCTASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2005014539
Kind Code:
A3
Abstract:
HMGCo-A reductase inhibitor compounds of formula (I) useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided.

Inventors:
KENNEDY ROBERT MICHAEL (US)
PARK WILLIAM KEUN-CHAN (US)
ROTH BRUCE DAVID (US)
SONG YUNTAO (US)
TRIVEDI BHARAT KALIDAS (US)
Application Number:
IB2004002540W
Publication Date:
May 12, 2005
Filing Date:
July 30, 2004
Export Citation:
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Assignee:
WARNER-LAMBERT COMPANY LLC
KENNEDY, ROBERT, MICHAEL
PARK, WILLIAM, KEUN-CHAN
ROTH, BRUCE, DAVID
SONG, YUNTAO
TRIVEDI, BHARAT, KALIDAS
International Classes:
C07C303/40; C07C311/13; C07D207/33; C07D207/34; C07D207/36; C07D319/06; C07D401/04; C07D401/12; C07D403/12; C07D405/06; C07D405/12; C07D405/14; C07D413/12; C07D413/14; C07D207/32; (IPC1-7): A61K31/40; C07D207/34; A61P3/06; A61K31/4025; C07D401/04; C07D401/12; C07D207/32; C07D405/06; C07D319/06; C07C311/11
Other References:
GRAUL A ET AL: "Atorvastatin Calcium" DRUGS OF THE FUTURE, BARCELONA, ES, vol. 22, no. 9, 1997, pages 956-968, XP000904817 ISSN: 0377-8282
JAHNG Y: "Design of a new class of HMG-CoA reductase inhibitors" DRUGS OF THE FUTURE, BARCELONA, ES, vol. 20, no. 4, 1995, pages 387-404, XP001055605 ISSN: 0377-8282
ROTH B D ET AL: "Inhibitors of Cholesterol Biosynthesis. 3. Tetrahydro-4-hydroxy-6-(2- (1H-pyrrol-1-yl)ethyl)-2H-pyran-2-one Inhibitors of HMG-CoA Reductase. 2. Effects of Introducing Substituents at Positions Three and Four of the Pyrrole Nucleus" JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 34, no. 1, January 1991 (1991-01), pages 357-366, XP002922115 ISSN: 0022-2623
PROCOPIOU P A ET AL.: "Inhibitors of Cholesterol Biosynthesis. 2. 3,5-Dihydroxy-7-(N-pyrrolyl)-6-heptenoates , a Novel Series of HMG-CoA Reductase Inhibitors" JOURNAL OF MEDICINAL CHEMISTRY., vol. 36, no. 23, 1993, pages 3658-3662, XP002303229 USAMERICAN CHEMICAL SOCIETY. WASHINGTON.
HLASTA D J ET AL: "Steric Effects on the Regioselectivity of an Azide-Alkyne Dipolar Cycloaddition Reaction: The Synthesis of Human Leukocyte Elastase Inhibitors" JOURNAL OF ORGANIC CHEMISTRY., vol. 59, no. 21, 1994, pages 6184-6189, XP002313042 USAMERICAN CHEMICAL SOCIETY. EASTON.
BAUDIN J B ET AL: "Unsaturated sulfinamides. X. A simple and efficient preparation of N,N-disubstituted (1-alkyne)- or (E)-(1-alkene)sulfinamides and their conversion into the corresponding sulfinates or sulfonamides" SYNLETT., no. 11, 1992, pages 911-913, XP001204490 DETHIEME VERLAG, STUTTGART.
BABIN P ET AL: "Electrophilic properties of sulfamoyl chloride. Application to the synthesis of .alpha.,.beta.-acetylenic sulfonamides" JOURNAL OF CHEMICAL RESEARCH. SYNOPSES, no. 1, 1982, pages 16-17, XP009042402 GBLONDON
ELLING H A, MAK H J: "Acetylenic sulfinamides: a novel class of compounds" SYNTHETIC COMMUNICATIONS., vol. 6, no. 2, 1976, pages 129-134, XP009042401 USMARCEL DEKKER, NEW YORK, NY.
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