PYRROLE DERIVATIVE OR PHARMACEUTICALLY OR SITOLOGICALLY ACCEPTABLE SALT THEREOF, AND COMPOSITION FOR PREVENTION, AMELIORATION OR TREATMENT OF GASTROINTESTINAL DISORDERS COMPRISING SAME AS ACTIVE INGREDIENT

WIPO Patent Application WO/2023/090942

A1

The present invention relates to a pyrrole derivative or a pharmaceutically or sitologically acceptable salt thereof, and a composition for the prevention, amelioration or treatment of gastrointestinal disorders, comprising same as an active ingredient. Through the results, it can be confirmed that the pharmacokinetic parameters, oral bioavailability and storage stability of the compound of the present invention are remarkably improved due to deuteration of the terminal methylamine moiety. The pyrrole derivative or the pharmaceutically or sitologically acceptable salt thereof of the present invention exhibits excellent anticancer activity in addition to excellent proton pump inhibitory activity, and has improved pharmacokinetic parameters and chemical stability, and thus can be effectively used in the prevention, amelioration or treatment of gastrointestinal disorders, including gastric cancer.

YOO JAE HO (KR)
IM SONG I (KR)
LEE KYU HANG (KR)
KIM DONG HOON (KR)
OH EUN HYE (KR)
LEE DONG YEOUL (KR)
JUNG KI MOON (KR)
KWAK DA JIN (KR)
KIM SEO YEON (KR)
KIM YE RIN (KR)
MIN CHANG HO (KR)

PCT/KR2022/018323

May 25, 2023

November 18, 2022

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HANA PHARM CO LTD (KR)

C07D207/36; A23L33/10; A61K31/40; A61K31/4439; A61P1/00; A61P1/04; A61P35/00; C07D401/04; C07D401/12

EP3521281A1	2019-08-07
JP2010520153A	2010-06-10
KR20100101138A	2010-09-16
KR101613245B1	2016-04-18
JP2018503675A	2018-02-08

HANSUNG INTELLECTUAL PROPERTY (KR)

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