Title:
PYRROLE RING-CONTAINING PROTON PUMP INHIBITOR BEING HEMIFUMARATE AND CRYSTAL FORM THEREOF, INTERMEDIATE AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/078594
Kind Code:
A1
Abstract:
Disclosed are a pyrrole ring-containing proton pump inhibitor being hemifumarate, crystal form, intermediate and medical use thereof. In particular, the present invention relates to a pyrrole ring-containing proton pump inhibitor being a hemifumarate, a crystal form, an intermediate, and a preparing method and medical use thereof, i.e., 2-(3-((2-(2-fluorophenyl)-4-((methylamino)methyl)-1H-pyrrole-1-yl)sulfonyl)phenoxy)-N-methyl-acetamide hemifumarate as represented by formula (I), and a salt-forming method through 2-(3-((2-(2-fluorophenyl)-4-((methylamino)methyl)-1H-pyrrole-1-yl)sulfonyl)phenoxy)-N-methyl-acetamide and fumaric acid, and characterizes a crystal form of the hemifumarate. In the present invention, the hemifumarate and the crystal form thereof have better stability, exhibit superior biological activity and have good gastric acid inhibition.
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Inventors:
YU JUN (CN)
ZHU QIANG (CN)
YANG BAOHAI (CN)
ZHU QIANG (CN)
YANG BAOHAI (CN)
Application Number:
PCT/CN2015/094958
Publication Date:
May 26, 2016
Filing Date:
November 18, 2015
Export Citation:
Assignee:
JIANGSU HANSOH PHARMACEUTICAL (CN)
International Classes:
C07D207/48; A61K31/40; A61P1/04; C07C51/41; C07C57/15
Domestic Patent References:
WO2014075575A1 | 2014-05-22 |
Foreign References:
CN104447490A | 2015-03-25 | |||
CN104447491A | 2015-03-25 | |||
CN101300229A | 2008-11-05 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
北京戈程知识产权代理有限公司 (CN)
北京戈程知识产权代理有限公司 (CN)
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