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Patent Searching and Data


Title:
PYRROLIDINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2019/112024
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel compound which has CGRP receptor antagonistic action and is useful for treatment of various diseases mediated by CGRP receptors. The present invention pertains to a pyrrolidine compound represented by formula (I) or a pharmaceutically acceptable salt thereof [in the formula, R1 or the like represents -OH, -OZ1, NH2, -NHZ2, -NZ2Z3, or the like]. The compound according to the present invention or a pharmaceutically acceptable salt thereof has excellent CGRP receptor antagonistic action and is useful as a therapeutic drug for various diseases mediated by CGRP receptors.

Inventors:
KONDO, Atsushi (Kissei Pharmaceutical Co. Ltd., 4365-1, Hotaka-Kashiwabara, Azumino-sh, Nagano 04, 〒3998304, JP)
MORITA, Naohide (Kissei Pharmaceutical Co. Ltd., 4365-1, Hotaka-Kashiwabara, Azumino-sh, Nagano 04, 〒3998304, JP)
ISHIKAWA, Takehiro (Kissei Pharmaceutical Co. Ltd., 4365-1, Hotaka-Kashiwabara, Azumino-sh, Nagano 04, 〒3998304, JP)
YOSHIDA, Masako (Kissei Pharmaceutical Co. Ltd., 4365-1, Hotaka-Kashiwabara, Azumino-sh, Nagano 04, 〒3998304, JP)
MORIYAMA, Akihiro (Kissei Pharmaceutical Co. Ltd., 4365-1, Hotaka-Kashiwabara, Azumino-sh, Nagano 04, 〒3998304, JP)
WANAJO, Isao (Kissei Pharmaceutical Co. Ltd., 4365-1, Hotaka-Kashiwabara, Azumino-sh, Nagano 04, 〒3998304, JP)
Application Number:
JP2018/045009
Publication Date:
June 13, 2019
Filing Date:
December 07, 2018
Export Citation:
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Assignee:
KISSEI PHARMACEUTICAL CO., LTD. (19-48, Yoshino Matsumoto-sh, Nagano 10, 〒3998710, JP)
International Classes:
C07D401/14; A61K31/501; A61K31/5377; A61P25/06; C07D403/12; C07D405/14
Domestic Patent References:
WO2017027345A12017-02-16
WO2018016547A12018-01-25
Foreign References:
JP2007519729A2007-07-19
JP2009539997A2009-11-19
JP2005538959A2005-12-22
Attorney, Agent or Firm:
YANAGI, Nobuko et al. (Intellectual Property, Kissei Pharmaceutical Co. Ltd., 19-48, Yoshino, Matsumoto-sh, Nagano 10, 〒3998710, JP)
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