Title:
PYRROLIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2018/016547
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel compound which has an antagonistic activity against CGRP receptors and is useful for the treatment of various diseases associated with CGRP receptors. That is, the present invention relates to a pyrrolidine derivative represented by formula (I) or a pharmacologically acceptable salt thereof. In the formula, W represents a ring, X represents a carbon atom or the like, Y1 to Y4 independently represent a carbon atom or the like, and R1 to R7 independently represent an alkyl group or the like. The compound or a pharmacologically acceptable salt thereof according to the present invention has an excellent antagonistic activity against CGRP receptors and is useful as a therapeutic agent for various diseases associated with CGRP receptors.
Inventors:
KONDO ATSUSHI (JP)
MORITA NAOHIDE (JP)
ISHIKAWA TAKEHIRO (JP)
YOSHIDA MASAKO (JP)
MORIYAMA AKIHIRO (JP)
WANAJO ISAO (JP)
MORITA NAOHIDE (JP)
ISHIKAWA TAKEHIRO (JP)
YOSHIDA MASAKO (JP)
MORIYAMA AKIHIRO (JP)
WANAJO ISAO (JP)
Application Number:
PCT/JP2017/026169
Publication Date:
January 25, 2018
Filing Date:
July 20, 2017
Export Citation:
Assignee:
KISSEI PHARMACEUTICAL (JP)
International Classes:
C07D401/14; A61K31/501; A61K31/506; A61P9/00; A61P25/06; A61P43/00; C07D403/12; C07D403/14; C07D405/14
Domestic Patent References:
| WO2015161011A1 | 2015-10-22 | |||
| WO2012058645A1 | 2012-05-03 |
Foreign References:
| JP2007519729A | 2007-07-19 | |||
| JP2010529119A | 2010-08-26 | |||
| JP2009544709A | 2009-12-17 | |||
| US20110098269A1 | 2011-04-28 | |||
| JP2002506878A | 2002-03-05 |
Other References:
LUO , GUANGLIN ET AL.: "Calcitonin gene-related peptide (CGRP) receptor antagonists: Novel aspartates and succinates", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, no. 8, 2012, pages 2912 - 2916, XP055452762, ISSN: 0960-894X
See also references of EP 3459941A4
See also references of EP 3459941A4
Attorney, Agent or Firm:
YANAGI, Nobuko et al. (JP)
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