Title:
PYRROLIDINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2017/071536
Kind Code:
A1
Abstract:
Provided herein are compounds of the formula (I), as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment or prevention of mGluR5 mediated disorders, such as acute and/or chronic neurological disorders, cognitive disorders and memory deficits, as well as acute and chronic pain.
Inventors:
CHEN LI (CN)
DUAN YUEJIAO (CN)
SHE JIN (CN)
WU CHENGDE (CN)
DUAN YUEJIAO (CN)
SHE JIN (CN)
WU CHENGDE (CN)
Application Number:
PCT/CN2016/102946
Publication Date:
May 04, 2017
Filing Date:
October 21, 2016
Export Citation:
Assignee:
HUA MEDICINE (SHANGHAI) LTD (CN)
International Classes:
C07D401/08; A61K31/4439; A61P25/28
Domestic Patent References:
| WO2014124560A1 | 2014-08-21 |
Foreign References:
| CN101287726A | 2008-10-15 |
Other References:
KOMEYAMA, KIMIHIRO ET AL.: "Intramolecular Alkynylcyclopropanation of Olefins Catalyzed by Bi(OTf)3:Stereoselective Synthesis of 1-Alkynyl-3-azabicyclo[3.1.0]hexanes", ANGEWANDTE CHEMIE , INTERNATIONAL EDITION, vol. 48, no. 52, 31 December 2009 (2009-12-31), pages 9875 - 9878, XP055378992
RODRIGUEZ ET AL., MOL PHARMACOL, vol. 78, 2010, pages 1105 - 1123
See also references of EP 3371163A4
RODRIGUEZ ET AL., MOL PHARMACOL, vol. 78, 2010, pages 1105 - 1123
See also references of EP 3371163A4
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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